{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T12:45:45Z","timestamp":1777121145245,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T00:00:00Z","timestamp":1092268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Comparatively few studies with at least 5 years of follow\u2010up are available that describe the use of implants in prosthetic rehabilitation of partially edentulous patients. Randomized, controlled clinical studies that evaluated the effect of different surface designs of screw\u2010shaped implants on the outcome of treatment are also sparse.<\/jats:p><jats:p><jats:bold>Objective: <\/jats:bold> To determine, in a prospective randomized, controlled clinical trial, the outcome of restorative therapy in periodontitis\u2010susceptible patients who, following basic periodontal therapy, had been restored with implants with either a machined\u2010 or a rough\u2010surface topography.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Fifty\u2010one subjects (mean age, 59.5 years), 20 males and 31 females who, following treatment of moderate\u2010to\u2010advanced chronic periodontitis, required implant therapy for prosthetic rehabilitation were recruited. Seventeen of the patients were current smokers. Following the active treatment, all subjects were included in an individually designed maintenance program. A total of 56 fixed partial dentures (FPDs) and a total of 149 screw\u2010shaped, and self\u2010tapping implants (Astra Tech\u00ae implants) \u2013 83 in the maxilla and 66 in the mandible \u2013 were installed in a two\u2010stage procedure. Each patient received a minimum of two implants and by randomization every second implant that was installed had been designed with a machined surface and the remaining with a roughened Tioblast\u00ae surface. Abutment connection was performed 3\u20136 months after implant installation. Clinical and radiographical examinations were performed following FPD connection and once a year during a 5\u2010year follow\u2010up period. The analysis of peri\u2010implant bone\u2010level alterations was performed on subject, FPD and implant levels.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Four patients and four FPDs were lost to the 5 years of monitoring. One implant (machined surface) did not properly integrate (early failure), and was removed at the time of abutment connection. Three implants were lost during function and a further eight implants could not be accounted for at the 5\u2010year follow\u2010up examination. The overall failure rate at 5 years was 5.9% (subject level), 5.3% (FPD level) and 2.7% (implant level). Radiographic signs of loss of osseointegration were not found at any of the implants during the 5\u2010year observation period. During the first year in function there was on average 0.33\u2003(SD,\u20030.61)\u2003mm loss of peri\u2010implant marginal bone on the subject and FPD levels and 0.31\u2003(0.81)\u2003mm on the implant level. During the subsequent 4 years, the peri\u2010implant bone\u2010level alterations were small. The calculated annual change in peri\u2010implant bone level was \u22120.02 (0.15) on subject and FPD levels and \u22120.03 (0.20) on the implant level. Thus, the mean total bone\u2010level change over the 5\u2010year interval amounted to 0.41\u2003mm on all three levels of analysis. In the interval between baseline and 5 years, the machined and the Tioblast\u00ae implants lost on average 0.33 and 0.48\u2003mm, respectively (<jats:italic>p<\/jats:italic>&gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The present randomized, controlled clinical trial that included partially edentulous periodontitis\u2010susceptible subjects demonstrated that bone loss (i) during the first year of function as well as annually thereafter was small and (ii) did not vary between implants with machined\u2010 or rough\u2010surface designs.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2004.00568.x","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T15:57:05Z","timestamp":1092326225000},"page":"713-724","source":"Crossref","is-referenced-by-count":171,"title":["Oral rehabilitation with implant\u2010supported fixed partial dentures in periodontitis\u2010susceptible subjects"],"prefix":"10.1111","volume":"31","author":[{"given":"Jan L.","family":"Wennstr\u00f6m","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Ekestubbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Gr\u00f6ndahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lindhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"321","article-title":"A 3\u2010year clinical study of Astra dental implants in the treatment of edentulous mandibles","volume":"7","author":"Arvidson K.","year":"1992","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_3_1","first-page":"646","article-title":"Br\u00e5nemark system implants in the posterior maxilla","volume":"15","author":"Bahat O.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2003.03315.x"},{"key":"e_1_2_6_5_1","first-page":"633","article-title":"The longitudinal clinical effectiveness of ITI solid\u2010screw implants in partially edentulous patients","volume":"15","author":"Behneke A.","year":"2000","journal-title":"International Journal of Oral & Maxillofacial Implants"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.12.x"},{"key":"e_1_2_6_7_1","first-page":"165","article-title":"Radiographic assessment of marginal bone loss","volume":"20","author":"Bj\u00f6rn H.","year":"1969","journal-title":"Odontologisk Revy"},{"key":"e_1_2_6_8_1","first-page":"132","volume-title":"Osseointegrated Implants in the Treatment of the Edentulous Jaw. 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