{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:29:22Z","timestamp":1794266962170,"version":"4.9.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> This randomized clinical trial presents a 12\u2010month follow\u2010up of the clinical and microbiological results after application of minocycline microspheres as an adjunct to mechanical treatment of incipient peri\u2010implant infections compared with an adjunctive treatment using 1% chlorhexidine gel application.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Thirty\u2010two subjects with probing depth 4\u2003mm, combined with bleeding and\/or exudate on probing and presence of putative pathogenic bacteria were given oral hygiene instructions and mechanical treatment of infected areas adjacent to implants. The subjects were then randomly assigned adjunctive subgingival antimicrobial treatment using either chlorhexidine gel or minocycline microspheres. Sixteen patients in the minocycline group and 14 in the chlorhexidine group completed the study. Follow\u2010up examinations were carried out after 10 days, 1, 2, 3, 6, 9 and 12 months.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The adjunctive use of minocycline microspheres resulted in improvements of probing depths and bleeding scores, whereas the adjunctive use of chlorhexidine only resulted in limited reduction of bleeding scores. For the deepest sites of the treated implants in the minocycline group, the mean probing depth was reduced from 5.0 to 4.4\u2003mm at 12 months. This study could not show any significant difference in the levels of bacterial species or groups at any time point between the two antimicrobial agents tested. The present findings encourage further studies on adjunctive use of minocycline microspheres in the treatment of peri\u2010implant lesions.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The use of a local antibiotic as an adjunct to mechanical treatment of incipient peri\u2010implantitis lesions demonstrated improvements in probing depths that were sustained over 12 months.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00919.x","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T07:57:35Z","timestamp":1144396655000},"page":"362-369","source":"Crossref","is-referenced-by-count":173,"title":["Topical minocycline microspheres <i>versus<\/i> topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri\u2010implant infections: a randomized clinical trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Stefan","family":"Renvert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lessem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"106","article-title":"Microbial findings of deep peri\u2010implant bone defects","volume":"12","author":"Augthun M.","year":"1997","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030101.x"},{"key":"e_1_2_11_4_1","first-page":"239","article-title":"Periimplant\u00e4re Therapie mittels subgingivaler Irrigation und intraoperativem Einsatz von Salzstrahlger\u00e4ten","volume":"7","author":"Bra\u00df M.","year":"1991","journal-title":"Zeitschrift f\u00fcr Zahn\u00e4rzliche Implantologie"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.11.962"},{"key":"e_1_2_11_7_1","first-page":"9","article-title":"Infektionen bei osseointegrierten Implantaten \u2010 Hintergr\u00fcnde und klinische Implikationen","volume":"1","author":"Flemmig T. 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