{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:20:10Z","timestamp":1789388410808,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold>To test the hypothesis that the olfactory bulbectomy model of depression in rats could influence susceptibility to ligature\u2010induced periodontitis, and that chronic treatment with the anti\u2010depressant drug tianeptine could attenuate this effect.<\/jats:p><jats:p><jats:bold>Material and Methods:<\/jats:bold>Tianeptine was given twice daily (10\u2003mg\/kg, i.p.) during the entire experiment, starting 29 days before induction of olfactory bulbectomy and periodontitis. Olfactory bulbectomized (OB) rats and sham\u2010operated rats were given saline in a similar manner. Periodontal disease was assessed when the ligatures had been in place for 21 days. Two hours before decapitation, rats were injected with lipopolysaccharide (LPS;100\u2003\u03bcg\/kg, i.p.) to induce a robust immune and stress response.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Compared with sham\u2010operated controls, OB rats developed significantly more periodontal bone loss, exhibited characteristic behavioural responses in a novel open field test, and showed a decreased expression of glucocorticoid receptors (GRs) in the hippocampus. LPS provoked a significantly larger increase in circulating levels of the stress hormone corticosterone and the cytokine transformation growth factor (TGF)\u20101\u03b2 but smaller tumour necrosis factor (TNF)\u2010\u03b1 levels. Tianeptine treatment of OB rats significantly inhibited peridodontal bone loss, normalized behavioural responses, enhanced TGF\u20101\u03b2 levels, and abolished TNF\u2010\u03b1 decrease, but did not attenuate the increased corticosterone response and the decreased hippocampal GR expression.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>These experimental results are consistent with an emerging literature showing that life stress, anxiety, depression, pathological grief, and poor coping behaviour may dysregulate regulatory mechanisms within the brain involved in immune regulation, and thereby alter immune responses and influence the susceptibility\/resistance to inflammatory disorders.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00935.x","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T12:00:03Z","timestamp":1149163203000},"page":"469-477","source":"Crossref","is-referenced-by-count":57,"title":["Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti\u2010depressant tianeptine"],"prefix":"10.1111","volume":"33","author":[{"given":"Torbj\u00f8rn","family":"Breivik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yngvar","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond","family":"Myhrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Fonnum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Osmundsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Murison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Gjermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Von H\u00f6rsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Kristian","family":"Opstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90066-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5234.286"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00087.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.00774.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1001903221046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035005285.x"},{"key":"e_1_2_8_8_1","first-page":"627","volume-title":"Psychneuroimmunology. 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