{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:56:39Z","timestamp":1761216999441},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives: <\/jats:bold> It has been demonstrated that extracellular matrix molecules are involved in cyclosporine\u2010induced gingival overgrowth (GO). However, for many of these molecules, it remains unclear whether their abundance is modulated on the protein and gene expression level.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> To contribute to this clarification, we have analysed the protein and mRNA expression of type\u2010I collagen (COL1) and decorin (DC) in native specimens obtained from five patients with GO, and matched normal tissue using indirect immunofluorescence (IIM), in situ hybridization (ISH) and quantitative polymerase chain reaction (PCR).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> IIF revealed a largely co\u2010localized although remarkably increased abundance for COL1 and DC in GO. This increase coincided with an up\u2010regulated gene expression observed for both molecules, as detected by ISH and quantitative PCR.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Analysis of our data clearly demonstrates elevated levels for COL1 and DC and shows for the first time in native human tissue that involvement of these genes in GO is not confined to the protein level but also includes the transcriptional level.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00937.x","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T12:00:03Z","timestamp":1149163203000},"page":"510-516","source":"Crossref","is-referenced-by-count":12,"title":["Elevated levels of gene expression for collagen and decorin in human gingival overgrowth"],"prefix":"10.1111","volume":"33","author":[{"given":"Bettina","family":"Dannewitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Edrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Tomakidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Kohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Gabbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010J\u00f6rg","family":"Staehle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00776.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02216.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240101.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410060200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035001051.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.139.6.6049","article-title":"Differential expression of peroxisome proliferator\u2010activated receptor\u2010alpha,\u2010beta, and \u2010gamma during rat embryonic development","volume":"139","author":"Braissant O.","year":"1998","journal-title":"Endocrinology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1986.57.12.771"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2003.12.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780197"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.437"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<351::AID-JCP5>3.0.CO;2-U"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00207.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020410001692585"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1092"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.296"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.380"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb01140.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(88)80032-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.7.671"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00734.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00028.x"},{"key":"e_1_2_8_24_1","first-page":"371","article-title":"Cyclosporin A, effect on cytoskeleton and glycosaminoglycans in human gingival fibroblasts. Immunohistochemical and biochemical evaluation.","volume":"35","author":"Stabellini G.","year":"1991","journal-title":"European Journal of Basic and Applied Histochemistry"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240460209"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1366"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2230587"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023470709071"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.08.016"},{"key":"e_1_2_8_30_1","first-page":"47","article-title":"Interactions between thrombospondin and the small proteoglycan decorin","volume":"59","author":"Winnemoller M.","year":"1992","journal-title":"European Journal of Cell Biology"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1995.tb00160.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.6.565"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"H1816","DOI":"10.1152\/ajpheart.2001.281.4.H1816","article-title":"Time course of collagen and decorin changes in rat cardiac and skeletal musclepost\u2010MI","volume":"281","author":"Zimmerman S. D.","year":"2001","journal-title":"American Journal of Physiological. Heart and Circulation Physiology"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-051X.2006.00937.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-051X.2006.00937.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:30:07Z","timestamp":1696984207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-051X.2006.00937.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1600-051X.2006.00937.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-051x.2006.00937.x","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}