{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:06:03Z","timestamp":1784268363168,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Introduction: <\/jats:bold> The aim of this study was to compare serum antibody responses to periodontal pathogens after single\u2010visit full\u2010mouth ultrasonic debridement and quadrant\u2010wise therapy.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Thirty\u2010six subjects with chronic periodontitis were randomized into three groups: quadrant\u2010wise debridement in four visits, one\u2010visit full\u2010mouth debridement with water and with povidone iodine. Blood samples were collected before and immediately after treatment and 1, 3 and 6 months post\u2010therapy. Serum antibody titres and avidity to <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>, <jats:italic>Prevotella intermedia<\/jats:italic> and <jats:italic>Treponema denticola<\/jats:italic> were determined by enzyme\u2010linked immunosorbent assay (ELISA) and thiocyanate ELISA, respectively.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> IgG titres to <jats:italic>P. gingivalis<\/jats:italic> significantly decreased at 1, 3 and 6 months in full\u2010mouth debridement with water group, while significant reductions were seen only at 3 and 6 months after quadrant\u2010wise debridement. Both full\u2010mouth groups showed significant reduction in IgG titres to <jats:italic>A. actinomycetemcomitans<\/jats:italic> at 3 and 6 months. Significant increases in antibody avidity to <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>A. actinomycetemcomitans<\/jats:italic> were noted 3 months following full\u2010mouth debridement with povidone.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Both full\u2010mouth and quadrant treatments generally resulted in a decrease in antibody titres and increase in antibody avidity. Full\u2010mouth debridement induced an earlier reduction of IgG titre to <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>A. actinomycetemcomitans<\/jats:italic>, than quadrant\u2010wise therapy.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00963.x","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T16:28:22Z","timestamp":1158251302000},"page":"632-638","source":"Crossref","is-referenced-by-count":26,"title":["Antibody response after single\u2010visit full\u2010mouth ultrasonic debridement <i>versus<\/i> quadrant\u2010wise therapy"],"prefix":"10.1111","volume":"33","author":[{"given":"Dongqing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kiji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.926"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00461.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00463.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00462.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00788.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb02127.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.781"},{"key":"e_1_2_12_9_1","first-page":"43","article-title":"Human immune responses to oral micro\u2010organisms I. 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