{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:00:20Z","timestamp":1778133620962,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims: <\/jats:bold> The aim of this study was to investigate the effects of smoking on the response to non\u2010surgical treatment for aggressive periodontitis.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Seventy\u2010nine patients with generalized aggressive periodontitis were included in the study; 20 were smokers. All patients received a course of non\u2010surgical periodontal therapy and outcomes assessed 10 weeks post\u2010operatively. Non\u2010responding patients were designated if they had 30% or more non\u2010responding deep sites.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> At baseline, bleeding scores were lower in smokers. There was no difference in baseline plaque, pocket depth (PD), recession or clinical attachment levels (CALs); when sites were selected by equal levels of CAL, increased recession was seen in smokers. Outcomes were poorer in smokers (mean PD change 1.75\u00b10.56 <jats:italic>versus<\/jats:italic> 2.23\u00b10.87\u2003mm). The odds ratio for 30% of sites not responding in smokers was 2.9; for 40% non\u2010responding it was 5.9. Smoking altered the distribution of site\u2010specific responses to increase specifically the number of non\u2010responding sites. There was no significant difference in responses between ex\u2010smokers and never\u2010smokers.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The results demonstrate that smoking is a major risk factor for poor response to initial treatment and emphasize the importance of smoking cessation in periodontal therapy.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00965.x","type":"journal-article","created":{"date-parts":[[2006,9,14]],"date-time":"2006-09-14T16:28:22Z","timestamp":1158251302000},"page":"671-676","source":"Crossref","is-referenced-by-count":40,"title":["Prognostic factors in the treatment of generalized aggressive periodontitis: II. Effects of smoking on initial outcome"],"prefix":"10.1111","volume":"33","author":[{"given":"Francis J.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnaz","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindhu","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagihan","family":"Bostanci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner","family":"Marcenes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Croucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-004-0043-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2001.280813.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005084.pub2","article-title":"Interventions for tobacco cessation in the dental setting","author":"Carr A.","year":"2006","journal-title":"Cochrane Database Systems and Reviews"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2003.00520.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.672"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.398"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2003.11.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.16"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00519.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00902.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00966.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00289.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03793.x"},{"key":"e_1_2_7_15_1","first-page":"15","article-title":"Outcomes associated with supportive periodontal therapy in smokers and nonsmokers","volume":"75","author":"Meinberg T. 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