{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:31:39Z","timestamp":1760887899912},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> The indispensable role of interleukin\u20106 receptor (IL\u20106R) in regulating IL\u20106 responses has been clearly established. We have previously reported that <jats:italic>IL6R<\/jats:italic> polymorphisms strongly influenced the serum levels of soluble IL\u20106R. In this study, we investigated the association between these genetic variations and periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Among the seven novel <jats:italic>IL6R<\/jats:italic> single\u2010nucleotide polymorphisms (SNPs) reported, we genotyped two important sites: the +48892 A\/C in exon 9 and the \u2212183 G\/A in the promoter region. The SNP in exon 9 results in Asp\u2192Ala substitution in the proteolytic cleavage site of IL\u20106R<jats:italic>\u03b1<\/jats:italic>. In total, 212 periodontitis cases and 210 healthy controls were genotyped using polymerase chain reaction, restriction fragment length polymorphisms and direct sequencing methods.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Analysis of the genotype distribution of the +48892 A\/C SNP in periodontitis patients and in controls revealed a suggestive association with aggressive (<jats:italic>p<\/jats:italic>=0.04) and chronic periodontitis (<jats:italic>p<\/jats:italic>=0.04). In addition, the carriage rate for the A allele was significantly higher in chronic periodontitis patients [<jats:italic>p<\/jats:italic>=0.02, odds ratio (OR)=2.25]. No association was found in the \u2212183 G\/A SNP. The two markers were in linkage disequilibrium (LD) (|<jats:italic>D<\/jats:italic>\u2032|=0.53).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> The <jats:italic>IL6R<\/jats:italic>+48892 A\/C polymorphism could act as a risk factor for periodontitis; however, further association and biological studies are needed.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00978.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T15:08:24Z","timestamp":1154963304000},"page":"704-709","source":"Crossref","is-referenced-by-count":26,"title":["Interleukin\u20106 receptor gene polymorphisms and periodontitis in a non\u2010smoking Japanese population"],"prefix":"10.1111","volume":"33","author":[{"given":"Johnah 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