{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:11:05Z","timestamp":1792656665346,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:<\/jats:bold>Matrix metalloproteinase\u20101 and \u20103 (MMP\u20101, MMP\u20103) represent proteinases that degrade macromolecules of the extracellular matrix. These enzymes play a fundamental role during destruction of periodontal tissues. Genetic polymorphisms were characterized in the promoter region of the MMP\u20101 and MMP\u20103 genes. The aim of this study was to investigate the relationship between these genetic variations with chronic periodontitis in a Brazilian population.<\/jats:p><jats:p><jats:bold>Material and Methods:<\/jats:bold>Non\u2010smoking subjects (<jats:italic>n<\/jats:italic>=114) exhibiting sites 5\u2003mm clinical attachment loss were recruited for study. Control subjects (<jats:italic>n<\/jats:italic>=109) should not exhibit clinical signals of periodontitis. MMP\u20101 (\u22121607 1G\/2G, \u2212519 A\/G) and MMP\u20103 (\u22121612 5A\/6A) gene promoter polymorphisms were genotyped using PCR\u2010RFLP methods.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Analysis of polymorphisms showed no differences in distribution of the \u22121607 1G\/2G and \u2212519 A\/G variants in the MMP\u20101 gene between the healthy and periodontitis group (<jats:italic>p<\/jats:italic>&gt;0.05). However, the distribution of genotype frequencies of the \u22121612 5A\/6A polymorphism in the MMP\u20103 gene showed that the 5A\/5A genotype was significantly more frequent in the periodontitis group (<jats:italic>p<\/jats:italic>=0.008). The same was not observed in the 5A\/6A genotype once only one 5A allele is carried. We also observed a trend to increase the frequency of the MMP\u20101\/MMP\u20103 haplotype (2G\/5A) in the periodontitis group (<jats:italic>p<\/jats:italic>=0.08).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>On the basis of the results, no significant association is found for the MMP\u20101 polymorphisms with susceptibility of periodontitis, while the MMP\u20103 gene polymorphism may contribute to periodontal tissue destruction during periodontitis in Brazilian subjects.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00979.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T15:08:24Z","timestamp":1154963304000},"page":"699-703","source":"Crossref","is-referenced-by-count":56,"title":["Genetic polymorphisms in the MMP\u20101 and MMP\u20103 gene may contribute to chronic periodontitis in a Brazilian population"],"prefix":"10.1111","volume":"33","author":[{"given":"Claudia Maria","family":"Astolfi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lu\u00eds","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Augusto","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina Leme Godoy","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Roberto Peres","family":"Line","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5s.474"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01073-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300202.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012545090-4\/50013-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00547.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00553.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.2001.0398"},{"key":"e_1_2_6_10_1","first-page":"4225","article-title":"Correlation between expression of the matrix metalloproteinase gene in ovarian cancers and an insertion\/deletion polymorphism its promoter region","volume":"59","author":"Kanamori Y.","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_6_11_1","first-page":"11","article-title":"Influence of interleukin (IL)\u20101 composite genotype on clinical variables in non\u2010smoking well\u2010maintained compliant patients with chronic periodontitis","volume":"29","author":"Konig J.","year":"2005","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.234"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730080201"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90126-Q"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(97)90025-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64011-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01649.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.356"},{"key":"e_1_2_6_20_1","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase\u20101 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter J. 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