{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:27:21Z","timestamp":1773293241351,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T00:00:00Z","timestamp":1158105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> The goal of this histometric study was to compare the healing process of dehiscence\u2010type defects treated by enamel matrix derivative (EMD) or guided tissue regeneration (GTR) under the effect of nicotine in the dog model.<\/jats:p><jats:p><jats:bold>Materials and Methods: <\/jats:bold> Eight mongrel dogs were used. Buccal osseous dehiscences were surgically created on the mesial roots of the mandibular third and fourth pre\u2010molars. The defects were exposed to plaque accumulation for 3 months. After this period, the defects were randomly assigned to one of the treatments: open flap debridement (OFD), EMD or GTR with a resorbable membrane. During 4 months, the dogs received subcutaneous administration of nicotine (2\u2003mg\/kg twice a day with a 12\u2003h interval between the applications). After this period, the animals were killed and the blocks were processed. The histometric parameters evaluated included gingival recession, epithelial length, connective tissue adaptation, new cementum and new bone.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> A superior length of new cementum was observed in the sites treated by EMD in comparison with OFD (<jats:italic>p<\/jats:italic>0.05). No statistically significant differences were observed between GTR and the other groups.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> In the presence of nicotine, EMD may promote more new cementum formation than OFD while GTR failed to provide a significant difference.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00989.x","type":"journal-article","created":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T07:42:22Z","timestamp":1158133342000},"page":"900-907","source":"Crossref","is-referenced-by-count":12,"title":["Enamel matrix derivative <i>versus<\/i> guided tissue regeneration in the presence of nicotine: a histomorphometric study in dogs"],"prefix":"10.1111","volume":"33","author":[{"given":"Suzana Peres","family":"Pimentel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Wilson","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Bezerra","family":"Saldanha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Zaffalon","family":"Casati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Francisco H.","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enilson A.","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11s.1138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2005.00240.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.38.4.244"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1989.tb00626.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1338"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00220.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1278"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.6.583"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.9.589"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.7.789"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90008-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90071-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5.387"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.9.797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.10.564"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00250.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260109.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb00901.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00854.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1094"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1600-051X.1997.tb00248.x","article-title":"Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins","volume":"24","author":"Hammarstrom L.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1600-051X.1997.tb00251.x","article-title":"Periodontal regeneration with enamel matrix derivative in one human experimental defect. 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