{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T07:25:47Z","timestamp":1794554747252,"version":"4.9.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T00:00:00Z","timestamp":1157932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective: <\/jats:bold> The <jats:italic>CARD15<\/jats:italic> gene encodes a protein that acts as an intracellular receptor of bacterial products, thus playing an important role in the innate immune response. Recently, <jats:italic>CARD15<\/jats:italic> gene variants have been identified as a cause of increased susceptibility to Crohn's disease. The present study aimed to examine a potential association of <jats:italic>CARD15<\/jats:italic> gene variants with aggressive periodontitis susceptibility.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> The three main known <jats:italic>CARD15<\/jats:italic> gene variants (p.R702W, p.G908R, and p.L1007fsX1008) were analysed by direct sequencing of exon 4, 8, and 11 of the gene in a total of 86 generalized aggressive periodontitis patients in comparison with 67 healthy controls.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The mutant allele frequencies of the <jats:italic>CARD15<\/jats:italic> variants were low in the generalized aggressive periodontitis group as well as in the control group and not significantly different (R702W: 3.5% versus 5.2%; G908R: 1.7% versus 1.5%; L1007fsX1008: 5.2% versus 4.5%). Two rare variants (A755V and R791Q), previously described only in patients with other inflammatory diseases, were observed in three patients having aggressive periodontitis but not in controls.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Unlike in Crohn's disease, our results did not show an association between the three main <jats:italic>CARD15<\/jats:italic> mutations and aggressive periodontitis. The role of rare variants remains unclear.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.00995.x","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T13:19:58Z","timestamp":1157980798000},"page":"779-783","source":"Crossref","is-referenced-by-count":9,"title":["<i>CARD15<\/i> gene variants in aggressive periodontitis"],"prefix":"10.1111","volume":"33","author":[{"given":"B.","family":"Noack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"G\u00f6rgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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