{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:02:14Z","timestamp":1778518934936,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T00:00:00Z","timestamp":1165881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Treatment with a natural bone mineral (NBM) and a guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. However, until now there are only very limited data on the long\u2010term clinical results following this regenerative technique.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> To present the 5\u2010year results of a prospective, randomized, controlled clinical study evaluating the treatment of deep intra\u2010bony defects either with open flap debridement (OFD) and a combination of an NBM and GTR (test) or OFD alone (control).<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Nineteen patients diagnosed with advanced chronic periodontitis, and each of whom displayed one intra\u2010bony defect, received randomly the test or the control treatment. Results were evaluated at baseline, at 1 and at 5 years following therapy.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> No statistically significant differences in any of the investigated parameters were observed at baseline between the two groups. At 1 year after therapy, the test group showed a reduction in mean probing depth (PD) from 9.1\u00b11.1 to 3.7\u00b10.8\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) and a change in mean clinical attachment level (CAL) from 10.4\u00b11.3 to 6.4\u00b11.2\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001). At 5 years, mean PD and CAL measured 4.3\u00b10.8 and 6.7\u00b11.6\u2003mm, respectively. At 5 years, both PD and CAL were statistically significantly improved compared with baseline (<jats:italic>p<\/jats:italic>&lt;0.001) without statistically significant differences between the 1\u2010 and 5\u2010year results. In the control group, mean PD was reduced from 8.9\u00b11.3 to 4.9\u00b11.2\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) and mean CAL changed from 10.6\u00b11.4 to 8.8\u00b11.5\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.01). At 5 years, mean PD and CAL measured 5.6\u00b11.1 and 9.1\u00b11.3\u2003mm, respectively, and were still statistically significantly improved compared with baseline (<jats:italic>p<\/jats:italic>&lt;0.01). No statistically significant differences were found between the 1\u2010 and 5\u2010year results. The test treatment, at both 1 and 5 years, yielded statistically significantly higher CAL gains than the control one (<jats:italic>p<\/jats:italic>&lt;0.01). Compared with baseline, at 5 years a CAL gain of 3\u2003mm was found in nine defects (90%) of the test group but in none of the defects treated with OFD alone.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> It was concluded that (i) treatment of intra\u2010bony defects with OFD+NBM+GTR may result in significantly higher CAL gains than treatment with OFD, and (ii) the clinical results obtained after both treatments can be maintained over a period of 5 years.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.01007.x","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T14:40:36Z","timestamp":1166020836000},"page":"72-77","source":"Crossref","is-referenced-by-count":52,"title":["Five\u2010year results of a prospective, randomized, controlled study evaluating treatment of intra\u2010bony defects with a natural bone mineral and GTR"],"prefix":"10.1111","volume":"34","author":[{"given":"Anton","family":"Sculean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni C.","family":"Chiantella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Donos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Brecx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080206.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012889.x"},{"key":"e_1_2_7_4_1","first-page":"109","article-title":"Periodontal regeneration with an antogenous bone\u2010Bio\u2010Oss composite graft and a Bio\u2010Gide membrane","volume":"21","author":"Camelo M.","year":"2001","journal-title":"The International Journal of Periodontics and Restoritave Dentistry"},{"key":"e_1_2_7_5_1","first-page":"321","article-title":"Clinical, radiographic, and histologic evaluation of human periodontal defects treated with Bio\u2010Oss\u00ae and Bio\u2010Gide\u00ae","volume":"18","author":"Camelo M.","year":"1998","journal-title":"The International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02402.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.672"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.341"},{"key":"e_1_2_7_10_1","first-page":"120","volume-title":"The Design and Analysis of Clinical Experiments","author":"Fleiss J.","year":"1986"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090302.x"},{"key":"e_1_2_7_12_1","first-page":"650","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Karring T.","year":"2003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00487.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00911.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260110.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01282.x"},{"key":"e_1_2_7_18_1","first-page":"19","article-title":"Human histologic evaluation of a bovine\u2010derived xenograft in the treatment of periodontal osseous defects","volume":"20","author":"Mellonig J.","year":"2000","journal-title":"The International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.2.158"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260702.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10192.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00758.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-004-0254-7"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1034\/j.1600-051x.2001.028005397.x","article-title":"Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. 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