{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:05:18Z","timestamp":1793765118929,"version":"4.6.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T00:00:00Z","timestamp":1163635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    This study was undertaken to describe a new surgical approach (minimally invasive surgical technique, MIST) and to evaluate preliminarily its clinical performance and patient perception associated with the application of enamel matrix derivative (EMD) in the treatment of isolated deep intra\u2010bony defects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Thirteen deep isolated intra\u2010bony defects in 13 patients were surgically accessed with the MIST. This technique was designed to limit the mesio\u2010distal flap extension and the corono\u2010apical reflection in order to reduce the surgical trauma and increase flap stability. The incision of the defect\u2010associated papilla was performed according to the principles of the papilla preservation techniques. EMD was applied on the debrided root surfaces. Stable primary closure of the flaps was obtained with internal modified mattress sutures. Surgery was performed with the aid of an operating microscope and microsurgical instruments. Clinical outcomes were collected at baseline and at 1 year. Intra\u2010operative and post\u2010operative patient perception was also recorded.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Early wound healing was uneventful: primary wound closure was obtained and maintained in all sites with the exception of one site with a small wound dehiscence at week 1. No oedema or haematoma were noted. Patients did not report any pain. Three patients experienced slight discomfort for 2\u2010days post\u2010operatively. The 1\u2010year clinical attachment level (CAL) gain was 4.8\u00b11.9\u2003mm. The 1\u2010year percent resolution of the defect was 88.7\u00b120.7%, and reached 100% of the baseline intra\u2010bony component in seven sites. Residual probing depths (PD) were 2.9\u00b10.8\u2003mm. Differences between baseline and 1\u2010year CAL and PD were both clinically and statistically highly significant (\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.0001). A minimal increase of 0.1\u00b10.9\u2003mm in gingival recession between baseline and 1 year was recorded (\n                    <jats:italic>p<\/jats:italic>\n                    =0.39).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This case cohort indicates that MIST associated with EMD resulted in excellent clinical improvements while limiting patient morbidity. These preliminary findings need to be confirmed in a larger study.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.01020.x","type":"journal-article","created":{"date-parts":[[2006,11,16]],"date-time":"2006-11-16T07:26:22Z","timestamp":1163661982000},"page":"87-93","source":"Crossref","is-referenced-by-count":225,"title":["A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra\u2010bony defects: a novel approach to limit morbidity"],"prefix":"10.1111","volume":"34","author":[{"given":"Pierpaolo","family":"Cortellini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio S.","family":"Tonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.675"},{"key":"e_1_2_7_3_1","first-page":"321","article-title":"Clinical radiographic, and histologic evaluation of human periodontal defects treated with Bio\u2010Oss\u00ae and Bio\u2010Gide","volume":"18","author":"Camelo M.","year":"1998","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2220108.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.559"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.341"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.254"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.261"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_7_10_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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