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In four experimental groups, chlorhexidine digluconate (CHX) 0.12% solution, 1% CHX gel, phenolic compounds solution (Listerine<jats:sup>\u00ae<\/jats:sup>), amine\/stannous fluoride solution (Meridol<jats:sup>\u00ae<\/jats:sup>) and saline solution as a control group were applied daily for 1\u2003min. The wound area was measured photographically and the epithelialization rate was determined histologically at 3, 7, 14 and 21 days post\u2010surgery.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The mean wound area and mean distance between the epithelial margins decreased significantly with time (<jats:italic>p<\/jats:italic>&lt;0.001) in experimental and control groups, with the greatest wound area reduction and rate of epithelialization on day 14. A significantly superior rate of wound epithelialization (<jats:italic>p<\/jats:italic>=0.03) was presented following use of 1% CHX gel and Listerine<jats:sup>\u00ae<\/jats:sup> and a comparatively inferior one when the Meridol<jats:sup>\u00ae<\/jats:sup> solution was applied.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Each tested antimicrobial agent when applied on an excisional wound with epithelial and connective tissue deficiency did not have a negative effect on the rate of wound closure. The best results were achieved with 1%CHX gel and Listerine<jats:sup>\u00ae<\/jats:sup>.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.01033.x","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T09:46:26Z","timestamp":1169113586000},"page":"164-171","source":"Crossref","is-referenced-by-count":41,"title":["Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats"],"prefix":"10.1111","volume":"34","author":[{"given":"Avital","family":"Kozlovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Artzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Hirshberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Israeli\u2010Tobias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb02088.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb00968.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb01945.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1980.tb02151.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100040301"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290512.x"},{"key":"e_1_2_7_8_1","first-page":"101","article-title":"A time\u2010related study of healing in the marginal periodontal\/root interface","volume":"12","author":"Bloml\u00f6f L.","year":"1988","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00657.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01273.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00640.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800671205"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345710500022501"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01025.x"},{"key":"e_1_2_7_15_1","first-page":"3","volume-title":"The Molecular and Cellular Biology of Wound Repair","author":"Clark R. 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