{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:10:54Z","timestamp":1790057454925,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T00:00:00Z","timestamp":1167782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> We aimed to study the impact of periodontal therapy on several bio\u2010markers related to vascular health.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Fifty\u2010five consecutive subjects (age range 30\u201364 years) having severe periodontitis received an intensive session of periodontal therapy under local anaesthesia and provided blood samples before and 1 and 7 and 30 days following therapy. High\u2010sensitivity assays were utilized to quantify serum concentrations of inflammatory markers [interleukin(IL)\u20101<jats:italic>\u03b2<\/jats:italic>, tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>], plasma haemostatic (D\u2010dimer) and endothelial soluble markers [soluble E\u2010selectin(s\u2010Es) and von Willebrand factor antigen (r\u2010WF:Ag)].<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Periodontal therapy elicited a significant activation of the haemostatic system (38% and 68% mean increases of plasma D\u2010dimer 1 and 7 days after therapy, respectively, <jats:italic>p<\/jats:italic>&lt;0.001), together with moderate endothelial dysfunction (10% and 30% mean increases at 24\u2003h in plasma soluble E\u2010selectin, <jats:italic>p<\/jats:italic>&lt;0.05 and von\u2010Willebrand factor, <jats:italic>p<\/jats:italic>&lt;0.01, respectively). D\u2010Dimer and s\u2010Es acute changes were significantly correlated with periodontal treatment time (<jats:italic>p<\/jats:italic>&lt;0.05). Cigarette smoking status and body mass index strongly influenced the acute release of IL\u20101<jats:italic>\u03b2<\/jats:italic> (<jats:italic>p<\/jats:italic>&lt;0.05), D\u2010dimer (<jats:italic>p<\/jats:italic>&lt;0.01) and s\u2010Es (<jats:italic>p<\/jats:italic>&lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Periodontal therapy represents a novel and reliable non\u2010drug\u2010induced model to investigate in vivo the interplay between inflammation, coagulation and endothelial cell activation.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.01037.x","type":"journal-article","created":{"date-parts":[[2007,1,3]],"date-time":"2007-01-03T19:51:16Z","timestamp":1167853876000},"page":"124-129","source":"Crossref","is-referenced-by-count":58,"title":["Acute effects of periodontal therapy on bio\u2010markers of vascular health"],"prefix":"10.1111","volume":"34","author":[{"given":"Francesco","family":"D'Aiuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Parkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio S.","family":"Tonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613379"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00163-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1055\/s-0038-1649654","article-title":"Adverse influence of cigarette smoking on the endothelium","volume":"70","author":"Blann A. 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