{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:44:48Z","timestamp":1791225888846,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> Regenerative periodontal therapy with a combination of platelet\u2010rich plasma (PRP)+a natural bone mineral (NBM)+guided tissue regeneration (GTR) has been shown to result in significantly higher probing depth reductions and clinical attachment\u2010level gains compared with treatment with open flap debridement alone. However, at present, it is unknown to what extent the use of PRP may additionally enhance the clinical outcome of the therapy compared with treatment with NBM+GTR.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> To clinically compare treatment of deep intra\u2010bony defects with NBM+PRP+GTR with NBM+GTR.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Thirty patients suffering from advanced periodontal disease, and each of whom displayed one advanced intra\u2010bony defect were randomly treated with a combination of either NBM+PRP+collagen membrane (GTR) or NBM+GTR. The following clinical parameters were evaluated at baseline and at 1 year after treatment: plaque index, gingival index, bleeding on probing, probing depth (PD), gingival recession and clinical attachment level (CAL). CAL changes were used as the primary outcome variable.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all patients. At 1 year after therapy, the sites treated with NBM+PRP+GTR showed a reduction in mean PD from 8.9\u00b12.3\u2003mm to 3.4\u00b12.0\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001) and a change in mean CAL from 10.9\u00b12.2\u2003mm to 6.4\u00b11.8\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001). In the group treated with NBM+GTR, the mean PD was reduced from 8.9\u00b12.5\u2003mm to 3.4\u00b12.3\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001), and the mean CAL changed from 11.1\u00b12.5\u2003mm to 6.5\u00b12.3\u2003mm (<jats:italic>p<\/jats:italic>&lt;0.001). In both groups, all sites gained at least 3\u2003mm of CAL. CAL gains of 4\u2003mm were measured in 80% (i.e. in 12 out of 15 defects) of the cases treated with NBM+PRP+GTR and in 87% (i.e. in 13 out of 15 defects) treated with NBM+GTR. No statistically significant differences in any of the investigated parameters were observed between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Within its limits, the present study has shown that (i) at 1 year after regenerative surgery with both NBM+PRP+GTR and NBM+GTR, significant PD reductions and CAL gains were found, and (ii) the use of PRP has failed to improve the results obtained with NBM+GTR.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2006.01044.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T15:03:15Z","timestamp":1169737395000},"page":"254-261","source":"Crossref","is-referenced-by-count":91,"title":["Effect of platelet\u2010rich plasma on the healing of intra\u2010bony defects treated with a natural bone mineral and a collagen membrane"],"prefix":"10.1111","volume":"34","author":[{"given":"Ferenc","family":"D\u00f6ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Husz\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Nikolidakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Gera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"529","article-title":"Plasma rich in growth factors","volume":"14","author":"Anitua E.","year":"1999","journal-title":"International Journal of Maxillofacial Implants"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130512.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01010.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00208.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012889.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01001.x"},{"key":"e_1_2_6_8_1","first-page":"49","article-title":"A reentry study on the use of bovine porous bone mineral, GTR, and platelet\u2010rich plasma in the regenerative treatment of intrabony defects in humans","volume":"25","author":"Camargo P. 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