{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:55:41Z","timestamp":1772754941112,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,18]],"date-time":"2007-12-18T00:00:00Z","timestamp":1197936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:<\/jats:bold>Prostaglandin E<jats:sub>2<\/jats:sub>(PGE<jats:sub>2<\/jats:sub>) is considered to be an important mediator of tissue destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs. COX\u20102, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation. A single nucleotide polymorphism of COX\u20102<jats:sup>\u2212765<\/jats:sup>has been shown to alter the expression of the COX\u20102 gene. The purpose of the present study was to evaluate the association of the COX\u20102<jats:sup>\u2212765<\/jats:sup>polymorphism and susceptibility to periodontitis in Taiwanese.<\/jats:p><jats:p><jats:bold>Material and Methods:<\/jats:bold>Eighty\u2010five cases of aggressive periodontitis (AgP), 343 cases of chronic periodontitis (CP) and 153 cases of healthy controls (HC) were recruited for the study. Genotypes of COX\u20102<jats:sup>\u2212765<\/jats:sup>were determined by polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP). The distribution of genotypes among groups was compared by logistic regression analyses. The risk for periodontitis associated with genotypes was calculated as the odds ratio (OR).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>The prevalence of the GC and CC genotypes was significantly lower in AgP (5%) and in CP (29%) compared with the HC (42%). The ORs for carriage of the \u2212765C allele (GC+CC<jats:italic>versus<\/jats:italic>GG) in AgP and CP were 0.068 (95% CI=0.020\u20130.173,<jats:italic>p<\/jats:italic>&lt;0.0001) and 0.571 (95% CI=0.385\u20130.849,<jats:italic>p<\/jats:italic>=0.006), respectively. After adjustment for age, gender and smoking status, the OR was 0.071 (95% CI=0.017\u20130.219) and 0.552 (95% CI=0.367\u20130.829) for AgP and CP, respectively.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>The results of the study suggest that the \u2212765G to C polymorphism of the COX\u20102 gene is associated with a decreased risk for periodontitis in Taiwanese, especially in AgP. However, the biological meaning needs further investigation.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2007.01167.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T11:05:19Z","timestamp":1282129519000},"page":"1-8","source":"Crossref","is-referenced-by-count":27,"title":["Cyclooxygenase\u20102 Gene<sup>\u2212765<\/sup>single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese"],"prefix":"10.1111","volume":"35","author":[{"given":"Ya\u2010Ping","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Chu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Yen","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Cheng","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050208"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.05.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050320"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00961.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/3.9.2303"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401211"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00806.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.18.2221"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1063"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0022-3565(24)29252-1","article-title":"Functional characterization of cyclooxygenase\u20102 polymorphisms","volume":"299","author":"Fritsche E.","year":"2001","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00027-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00978.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.8.4556"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/9550"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00492.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290905.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2003.00071.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200512-1839OC"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00553.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01030.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364239"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.0228.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00274-9"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1000-y"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb18804.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1627"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1065-7"},{"issue":"6","key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-051X.2005.00806.x","article-title":"Identification of genetic risk factors for periodontitis and possible mechanisms of action","volume":"32","author":"Loos B. 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