{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:11:07Z","timestamp":1792656667427,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T00:00:00Z","timestamp":1218758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims: <\/jats:bold> The aims of this study were to investigate (1) the matrix metalloproteinase\u20101 (MMP\u20101) promoter polymorphisms in severe chronic periodontitis (CP), (2) the relationship of periodontal therapy outcome with these genotypes, and (3) the gingival crevicular fluid (GCF) MMP\u20101 levels\u2013MMP\u20101 genotype correlation.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> Genomic DNA was obtained from the peripheral blood of 102 patients with severe CP and 98 periodontally healthy subjects. MMP\u20101 \u2212519A\/G and \u22121607 1G\/2G polymorphisms were determined by the polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) method. Fifty\u2010eight CP patients received non\u2010surgical periodontal therapy and were followed for 6 months. Clinical periodontal parameters and GCF samples were collected at baseline and at 6 months. GCF MMP\u20101 levels were analysed by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The distribution of MMP\u20101 genotypes did not significantly differ between the study groups. On the other hand, the \u22121607 2G allele frequency of severe CP patients was higher than that of healthy subjects. MMP\u20101 \u2212519G allele carriers had higher GCF MMP\u20101 levels and percentage of sites with 4\u20136\u2003mm clinical attachment level (CAL) compared with AA genotypes after non\u2010surgical periodontal therapy (<jats:italic>p<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> These data suggest that the \u22121607 2G polymorphic allele of the MMP\u20101 gene could be associated with susceptibility to severe CP in the Turkish population. It seems that \u2212519AG and GG genotypes could play a role in the outcome of periodontal therapy.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2008.01302.x","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T09:04:43Z","timestamp":1218791083000},"page":"862-870","source":"Crossref","is-referenced-by-count":35,"title":["Effect of MMP\u20101 promoter polymorphisms on GCF MMP\u20101 levels and outcome of periodontal therapy in patients with severe chronic periodontitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Demet","family":"Pirhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afig","family":"Berdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00142.x"},{"key":"e_1_2_7_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290109.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00979.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411930040020401"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00615.x"},{"key":"e_1_2_7_9_1","first-page":"106","volume-title":"Monographs in Oral Science","author":"Cimasoni G.","year":"1983"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300202.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00797.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00803.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01107.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00547.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb01814.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00553.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.2001.0398"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240110.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411000110030501"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(85)90039-1"},{"issue":"6","key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-051X.2005.00806.x","article-title":"Identification of genetic risk factors for periodontitis and possible mechanisms of action","volume":"32","author":"Loos B. G.","year":"2005","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(90)90126-Q"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1994.tb01100.x"},{"key":"e_1_2_7_24_1","first-page":"107","article-title":"Gingival sulcus bleeding \u2013 a leading symptom in initial gingivitis","volume":"15","author":"M\u00fchlemann H. R.","year":"1971","journal-title":"Helvetica Odontologica Acta"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030101"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00786.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007452"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00195.x"},{"key":"e_1_2_7_31_1","first-page":"5321","article-title":"A single nucleotid polymorphism in the matrix metalloproteinase\u20101 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter J. L.","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00810.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01190.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2004.01038.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01126.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.487"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(00)00102-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00835.x"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-051X.2008.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-051X.2008.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:22:35Z","timestamp":1697070155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-051X.2008.01302.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,12]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1111\/j.1600-051X.2008.01302.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-051x.2008.01302.x","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,12]]}}}