{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:53:19Z","timestamp":1772754799263,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T00:00:00Z","timestamp":1234224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim: <\/jats:bold> Several common single nucleotide polymorphisms (SNPs) of the cyclooxygenase\u20102 (COX\u20102) gene have been reported to be functional. The association between \u22121195GA, \u2212765GC and 8473TC of COX\u20102, and severe chronic periodontitis (CP) in a Chinese population was investigated.<\/jats:p><jats:p><jats:bold>Material and Methods: <\/jats:bold> 148 cases of healthy controls (control group) and 146 cases of severe CP were recruited in this study. Genotypes of \u22121195GA, \u2212765GC and 8473TC were determined by polymerase chain reaction restriction fragment length polymorphism (PCR\u2010RFLP). The distributions of genotypes and haplotypes were compared by <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test and the odds ratios (ORs) were calculated by logistic regression analysis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> The prevalence of the \u22121195A was more prevalent in CP group (60.62%) than control group (51.35%), and the distributions of the \u2212765C and 8473C were higher in control group (6.76% and 21.96%) compared with CP group (3.08% and 15.07%). Only genotype distribution of \u22121195GA was significant when <jats:italic>p<\/jats:italic>\u2010value was corrected for multiple testing (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>=0.033). The adjusted ORs for the \u22121195AA\/GA, \u2212765GC and 8473CC\/TC were 2.49 (95% CI=1.33\u20134.69, <jats:italic>p<\/jats:italic>=0.005), 0.45 (95% CI=0.20\u20131.04, <jats:italic>p<\/jats:italic>=0.061) and 0.67 (95% CI=0.41\u20131.11, <jats:italic>p<\/jats:italic>=0.118). Subjects with the haplotype AGT had a significantly higher risk of periodontitis than those with the most common haplotype GGT (OR=1.91, 95% CI=1.32\u20132.76, <jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>&lt;0.001).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> It suggests the \u22121195A variant is associated with an increased risk for severe CP.<\/jats:p>","DOI":"10.1111\/j.1600-051x.2008.01366.x","type":"journal-article","created":{"date-parts":[[2009,2,11]],"date-time":"2009-02-11T22:19:32Z","timestamp":1234390772000},"page":"198-203","source":"Crossref","is-referenced-by-count":25,"title":["Common single nucleotide polymorphisms in cyclooxygenase\u20102 and risk of severe chronic periodontitis in a Chinese population"],"prefix":"10.1111","volume":"36","author":[{"given":"Cheng\u2010Jie","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Min","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Ying","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.00989.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0513"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000214706.88621.da"},{"key":"e_1_2_6_6_1"},{"key":"e_1_2_6_7_1","first-page":"11","article-title":"[Buccal 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