{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:32:38Z","timestamp":1762101158286},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1673,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1111\/j.1600-051x.2011.01702.x","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T01:02:42Z","timestamp":1296608562000},"page":"318-325","source":"Crossref","is-referenced-by-count":38,"title":["Stimulants of Toll-like receptors 2 and 4 are elevated in saliva of periodontitis patients compared with healthy subjects"],"prefix":"10.1111","volume":"38","author":[{"given":"D. F.","family":"Lappin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sherrabeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Erridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,1]]},"reference":[{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1161\/hq1101.097803","article-title":"Relationship of periodontal disease to carotid artery intima-media wall thickness","volume":"21","author":"Beck","year":"2001","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0966-842X(96)10057-3","article-title":"The indigenous gastrointestinal microflora","volume":"4","author":"Berg","year":"1996","journal-title":"Trends in Microbiology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.4049\/jimmunol.177.12.8296","article-title":"Cutting edge","volume":"177","author":"Burns","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1128\/IAI.71.12.6799-6807.2003","article-title":"Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at Toll-like receptor 4 in human endothelial cells","volume":"71","author":"Coats","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0016-5085(69)80067-3","article-title":"Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons","volume":"56","author":"Drasar","year":"1969","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1600-051X.2004.00528.x","article-title":"A model of periodontitis in the rat","volume":"31","author":"Dumitrescu","year":"2004","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1600-051X.1985.tb00936.x","article-title":"Gram negative species associated with active destructive periodontal lesions","volume":"12","author":"Dzink","year":"1985","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB10|cit9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcm.2007.12.003","article-title":"The roles of pathogen-associated molecular patterns in atherosclerosis","volume":"18","author":"Erridge","year":"2008","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB11|cit10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000191413","article-title":"The roles of Toll-like receptors in atherosclerosis","volume":"1","author":"Erridge","year":"2009","journal-title":"Journal of Innate Immunity"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB12|cit11","first-page":"1","article-title":"The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4","volume":"20","author":"Erridge","year":"2010","journal-title":"British Journal of Nutrition"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB13|cit12","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/ajcn\/86.5.1286","article-title":"A high-fat meal induces low-grade endotoxemia","volume":"86","author":"Erridge","year":"2007a","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB14|cit13","doi-asserted-by":"crossref","first-page":"e9125","DOI":"10.1371\/journal.pone.0009125","article-title":"The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5","volume":"5","author":"Erridge","year":"2010","journal-title":"PLoS One"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB15|cit14","doi-asserted-by":"crossref","first-page":"24748","DOI":"10.1074\/jbc.M800352200","article-title":"Oxidised phospholipid inhibition of toll-like receptor (TLR) signalling is restricted to TLR2 and TLR4 - roles for CD14, LPS-binding protein and MD2 as targets for specificity of inhibition","volume":"283","author":"Erridge","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB9|cit15","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/ATVBAHA.109.194050","article-title":"Saturated fatty acids do not directly stimulate Toll-like receptor signaling","volume":"29","author":"Erridge","year":"2009","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cardiores.2006.11.004","article-title":"Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2","volume":"73","author":"Erridge","year":"2007b","journal-title":"Cardiovascular Research"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1902\/jop.2002.73.1.73","article-title":"Systemic release of endotoxins induced by gentle mastication","volume":"73","author":"Geerts","year":"2002","journal-title":"Journal of Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"Journal of Lipid Research"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1096\/fj.09-141929","article-title":"Tlr2 is critical for diet-induced metabolic syndrome in a murine model","volume":"24","author":"Himes","year":"2010","journal-title":"The Federation of American Societies for Experimental Biology Journal"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4049\/jimmunol.165.2.618","article-title":"Cutting edge","volume":"165","author":"Hirschfeld","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.2007.00335.x","article-title":"Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria","volume":"22","author":"Kikkert","year":"2007","journal-title":"Oral Microbiology and Immunology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-051X.2007.01048.x","article-title":"Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive-therapy periodontitis patients","volume":"34","author":"Lappin","year":"2007","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2009.11.011","article-title":"Emulsified lipids increase endotoxemia","volume":"22","author":"Laugerette","year":"2011","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1079-2104(96)80438-0","article-title":"Oral endotoxin in healthy adults","volume":"82","author":"Leenstra","year":"1996","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1161\/CIRCULATIONAHA.107.758524","article-title":"Bacteremia associated with toothbrushing and dental extraction","volume":"117","author":"Lockhart","year":"2008","journal-title":"Circulation"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1046\/j.0303-6979.2003.00418.x","article-title":"Effects of periodontitis and smoking on the microbiota of oral mucous membranes and saliva in systemically healthy subjects","volume":"30","author":"Mager","year":"2003","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1034\/j.1600-051x.2001.028010970.x","article-title":"Tongue coating and salivary bacterial counts in healthy\/gingivitis subjects and periodontitis patients","volume":"28","author":"Mantilla G\u00f3mez","year":"2001","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0403249101","article-title":"Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E","volume":"101","author":"Michelson","year":"2004","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1172\/JCI25482","article-title":"Modulation of atherosclerosis in mice by Toll-like receptor 2","volume":"115","author":"Mullick","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00125-007-0654-8","article-title":"C3H\/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet","volume":"50","author":"Poggi","year":"2007","journal-title":"Diabetologia"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1136\/gut.2006.108712","article-title":"Small intestinal bacterial overgrowth in patients with irritable bowel syndrome","volume":"56","author":"Posserud","year":"2007","journal-title":"Gut"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1161\/01.ATV.0000145979.82184.9f","article-title":"Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide","volume":"24","author":"Pussinen","year":"2004","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1902\/jop.2007.060321","article-title":"Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis","volume":"78","author":"Rogers","year":"2007","journal-title":"Journal of Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/dc09-1378","article-title":"Effect of periodontal treatment on glycemic control of diabetic patients","volume":"33","author":"Teeuw","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1902\/jop.2007.070056","article-title":"Chronic administration of lipopolysaccharide and proteases induces periodontal inflammation and hepatic steatosis in rats","volume":"78","author":"Tomofuji","year":"2007","journal-title":"Journal of Periodontology"},{"issue":"(S","key":"10.1111\/j.1600-051X.2011.01702.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-051X.2009.01417.x","article-title":"Periodontitis and risk for atherosclerosis","volume":"36","author":"Tonetti","year":"2009","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1161\/CIRCULATIONAHA.107.693382","article-title":"Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice","volume":"116","author":"Westerterp","year":"2007","journal-title":"Circulation"},{"key":"10.1111\/j.1600-051X.2011.01702.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/IAI.70.1.218-225.2002","article-title":"Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4","volume":"70","author":"Yoshimura","year":"2002","journal-title":"Infection and Immunity"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-051X.2011.01702.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-051X.2011.01702.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T10:19:53Z","timestamp":1625653193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-051X.2011.01702.x"}},"subtitle":["Oral TLR stimulants in periodontitis"],"short-title":[],"issued":{"date-parts":[[2011,2,1]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-051x.2011.01702.x","relation":{},"ISSN":["0303-6979"],"issn-type":[{"value":"0303-6979","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2,1]]}}}