{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:26:18Z","timestamp":1767824778192,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T00:00:00Z","timestamp":1316044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present randomized, double blind, parallel, 2\u2010arm clinical study was to examine the safety and efficacy of frequent applications of chlorhexidine chip (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>) and flurbiprofen chip (<jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content>) in patients with chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients were randomized into <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content> groups. Following <jats:styled-content style=\"fixed-case\">OHI<\/jats:styled-content> and scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>), baseline pocket depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) measurements, gingival recession and bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) were performed and repeated at week 4 and 8. The assigned chip was placed at weeks 0, 1, 2, 3, 5, 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction in the <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> group was 2.08\u00a0mm (7.17 to 5.09, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Mean <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction in the <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content> group was 2.27\u00a0mm (6.72 to 4.45, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Ninety\u2010seven percentage and 95% of these sites exhibited <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction \u22651\u00a0mm, while 38% and 34% of the sites exhibited <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> \u22653\u00a0mm (<jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>, respectively). Clinical attachment level gain (1.66 and 1.95\u00a0mm, respectively) was statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Baseline <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> dropped from 98% and 100% to 24% and 30% for the <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content> groups, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Frequent applications of <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FBP<\/jats:styled-content> chips resulted in a significant improvement in the periodontal condition in these sites. Furthermore studies will be required to compare this new treatment regimen to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> with single chip application.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-051x.2011.01779.x","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T17:13:42Z","timestamp":1316106822000},"page":"1037-1043","source":"Crossref","is-referenced-by-count":16,"title":["Multiple applications of flurbiprofen and chlorhexidine chips in patients with chronic periodontitis: a randomized, double blind, parallel, 2\u2010arms clinical trial"],"prefix":"10.1111","volume":"38","author":[{"given":"Eli E.","family":"Machtei","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam Health Care Campus and the Faculty of Medicine \u2013 Technion (I.I.T.) Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Hirsh","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam Health Care Campus and the Faculty of Medicine \u2013 Technion (I.I.T.) Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher","family":"Falah","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Graduate Dentistry Rambam Health Care Campus and the Faculty of Medicine \u2013 Technion (I.I.T.) Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Shoshani","sequence":"additional","affiliation":[{"name":"Dexcel Pharma Or Akiva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Avramoff","sequence":"additional","affiliation":[{"name":"Dexcel Pharma Or Akiva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Penhasi","sequence":"additional","affiliation":[{"name":"Dexcel Pharma Or Akiva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(91)90096-H"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.608"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540500398126"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070515"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00755.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290204.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.13"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1902\/jop.1999.70.5.490","article-title":"Two multi\u2010center studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis","volume":"70","author":"Garrett S.","year":"1999","journal-title":"Journal of Periodontology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060488"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02186.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280114.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01640.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090128"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.11.1058"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.11.1285"},{"key":"e_1_2_6_17_1","first-page":"1","article-title":"Systemic detection of doxycycline after local administration","volume":"10","author":"Kim T. 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