{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T04:13:36Z","timestamp":1794543216229,"version":"4.9.1"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T00:00:00Z","timestamp":1325635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present investigation aimed to analyse clinical and microbiological effects of systemic administration of metronidazole and amoxicillin combined with the One\u2010Stage\u2010Full\u2010Mouth\u2010Disinfection protocol (<jats:styled-content style=\"fixed-case\">OSFMD<\/jats:styled-content>) in generalized aggressive periodontitis patients (G\u2010AgP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty\u2010nine systemically healthy patients with G\u2010AgP were consecutively included. The test group (n\u00a0=\u00a019) received amoxicillin\u2010metronidazole combination (500\u00a0mg of each, three times a day for 7\u00a0days) and the <jats:styled-content style=\"fixed-case\">OSFMD<\/jats:styled-content>, the control group (n\u00a0=\u00a020) received the <jats:styled-content style=\"fixed-case\">OSFMD<\/jats:styled-content> and a placebo. In addition to clinical parameters subgingival plaque samples from moderate (4\u20135\u00a0mm) and deep (\u22656\u00a0mm) pocket sites were analysed for the presence of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>,<jats:italic> Prevotella intermedia<\/jats:italic>,<jats:italic> Porphyromonas gingivalis<\/jats:italic>,<jats:italic> Tannerella forsythia<\/jats:italic>, and <jats:italic>Treponema denticola<\/jats:italic> using polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both therapies led to a statistically significant decrease in clinical and microbiological parameters compared to baseline (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The most beneficial changes were observed in the test group which showed significantly greater improvements in probing depth and clinical attachment level and a lower prevalence of <jats:italic>Aggregatibacter actinomycetemcomitans, Treponema denticola,<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> compared to the control one (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic administration of metronidazole and amoxicillin as an adjunct to <jats:styled-content style=\"fixed-case\">OSFMD<\/jats:styled-content> therapy significantly improved clinical and microbiological outcomes in patients with G\u2010AgP over a 6\u2010month period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-051x.2011.01795.x","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T02:43:59Z","timestamp":1325731439000},"page":"284-294","source":"Crossref","is-referenced-by-count":79,"title":["Full\u2010mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"39","author":[{"given":"Mario","family":"Aimetti","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Division of Periodontology University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Division of Periodontology University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Guzzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Division of Periodontology University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology Division of Periodontology University of Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100468"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060473"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.10.973"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290108.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5-S.867"},{"key":"e_1_2_5_7_1","first-page":"1153","article-title":"Position paper. 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