{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:44:25Z","timestamp":1760888665892},"reference-count":80,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,9]],"date-time":"2012-04-09T00:00:00Z","timestamp":1333929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the influence of autogenous platelet concentrate (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) on the long\u2010term regeneration outcome 7\u00a0years after guided tissue regeneration (<jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content>) in deep intrabony periodontal defects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In 25 patients, two deep contra\u2010lateral intrabony defects were treated according to <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> (randomized split\u2010mouth\u2010design). In the test defects, <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> was additionally applied. After 7\u00a0years, healing results were assessed clinically by a blinded examiner and compared to baseline and 12\u2010months results. Furthermore, a tooth survival analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 7\u00a0years, 23 patients were available for survival analysis and 16 patients for split\u2010mouth analysis; 84% of the test and control teeth were still <jats:italic>in situ<\/jats:italic>. In both groups, the median attachment level of 10.5\u00a0mm [(25\/75%): test 9.0\/13.0, control 10.0\/12.0] at baseline was significantly (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.05) reduced to 6.0\u00a0mm [test 4.0\/6.8, control 5.0\/7.0] after 1\u00a0year. Six years later, it had increased again to 7.0\u00a0mm in test sites [5.3\/10.0] (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.05) and had remained stable in control sites [5.0\/7.8] (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Bleeding on Probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) had increased in both groups. During the last 6\u00a0years, only 26% of the patients received a structured supportive periodontal therapy in the clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within its limitations, the present study indicates that the clinical outcome of <jats:styled-content style=\"fixed-case\">GTR<\/jats:styled-content> therapy can be maintained over 7\u00a0years. However, the additional use of <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content> may even have a possibly negative influence on the long\u2010term stability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-051x.2012.01869.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T13:07:10Z","timestamp":1330434430000},"page":"457-465","source":"Crossref","is-referenced-by-count":13,"title":["Influence of autogenous platelet concentrate on combined <scp>GTR<\/scp>\/graft therapy in intrabony defects: a 7\u2010year follow\u2010up of a randomized prospective clinical split\u2010mouth study"],"prefix":"10.1111","volume":"39","author":[{"given":"Daniel","family":"Moder","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederike","family":"Taubenhansl","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Anton","family":"Hiller","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Schmalz","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University of Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Christgau","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology University of Regensburg Regensburg Germany"},{"name":"Private Practice D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"529","article-title":"Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants","volume":"14","author":"Anitua E.","year":"1999","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080454"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02035.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00563.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00317.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.9.589"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01001.x"},{"key":"e_1_2_8_9_1","first-page":"49","article-title":"A reentry study on the use of bovine porous bone mineral, GTR, and platelet\u2010rich plasma in the regenerative treatment of intrabony defects in humans","volume":"25","author":"Camargo P. 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