{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:16:33Z","timestamp":1789139793787,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,3]],"date-time":"2012-06-03T00:00:00Z","timestamp":1338681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>s) play a key role in the tissue destruction characteristic of chronic periodontitis. The purpose of this study was to investigate the association of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content> polymorphisms with chronic periodontitis in two populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 34 polymorphisms spanning 12 MMP and 2 TIMP genes were genotyped in 401 individuals from Brazil (99 cases with chronic periodontitis and 302 controls), and 274 individuals from the US (70 cases and 204 controls). Individuals were considered cases if presenting at least three teeth exhibiting sites of clinical attachment loss \u22655\u00a0mm in two different quadrants. Controls were characterized by absence of clinical attachment loss and no sites with probing depth &gt;3\u00a0mm. <jats:styled-content style=\"fixed-case\"><jats:italic>MMP3<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>TIMP1<\/jats:italic> mRNA<\/jats:styled-content> expression was evaluated in healthy and diseased periodontal tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>TIMP1<\/jats:italic><\/jats:styled-content> showed association with chronic periodontitis in the Brazilian population (for rs5906435, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.0004), whereas <jats:styled-content style=\"fixed-case\"><jats:italic>MMP3<\/jats:italic><\/jats:styled-content> showed association in the US population (for rs679620, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.0003; and rs650108, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.002) and in the Brazilian population (for rs639752, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.005). <jats:styled-content style=\"fixed-case\"><jats:italic>MMP3<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>TIMP1<\/jats:italic> mRNA<\/jats:styled-content> expression was significantly higher in diseased tissues when compared to control tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results further support a role for variations in <jats:styled-content style=\"fixed-case\"><jats:italic>MMP3<\/jats:italic><\/jats:styled-content> in chronic periodontitis and report a novel association with <jats:styled-content style=\"fixed-case\"><jats:italic>TIMP1<\/jats:italic><\/jats:styled-content>. These genes may be considered additional candidate genes for chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-051x.2012.01902.x","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T15:16:13Z","timestamp":1335539773000},"page":"707-716","source":"Crossref","is-referenced-by-count":43,"title":["MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression"],"prefix":"10.1111","volume":"39","author":[{"given":"Ariadne","family":"Letra","sequence":"first","affiliation":[{"name":"Department of Endodontics School of Dentistry, and Pediatric Research Center Medical School University of Texas Health Science Center at Houston Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Endodontics School of Dentistry, and Pediatric Research Center Medical School University of Texas Health Science Center at Houston Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Rylands","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology and Center for Craniofacial and Dental Genetics School of Dental Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcia M.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Oral Histology Bauru Dental School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Morphology Piracicaba School of Dentistry University of Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Wendell","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology and Center for Craniofacial and Dental Genetics School of Dental Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo P.","family":"Garlet","sequence":"additional","affiliation":[{"name":"Department of Oral Histology Bauru Dental School University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Departments of Oral Biology and Center for Craniofacial and Dental Genetics School of Dental Medicine University of Pittsburgh Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100513"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0906-6713.2002.003421.x","article-title":"Periodontal diagnoses and classification of periodontal diseases","volume":"2000","author":"Armitage G. C.","year":"2004","journal-title":"Periodontology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00979.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.030"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.01.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01798.x"},{"issue":"1","key":"e_1_2_6_9_1","first-page":"13","article-title":"Polymorphism in interleukin\u20101 beta gene and the risk of periodontitis in a Polish population","volume":"51","author":"Drozdzik A.","year":"2006","journal-title":"Advances in Medical Sciences"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.188"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00545.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350600963640"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00198.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00547.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb01814.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00030-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070159"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2003.09.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.04.005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.03.011"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730080201"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.05.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-007-0120-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100084"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.0906-6713.2002.03202.x","article-title":"Understanding the etiology of periodontitis: an overview of periodontal risk factors","volume":"2000","author":"Nunn M. E.","year":"2003","journal-title":"Periodontology"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.1.149"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.50.53"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.157801"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01447.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-010-9407-3"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01653.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01145.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00287.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300202.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060309"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00676.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01830.x"},{"key":"e_1_2_6_41_1","first-page":"360","article-title":"Understanding interobserver agreement: the Kappa Statistic","volume":"37","author":"Viera A.","year":"2005","journal-title":"Family Medicine"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.74226"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-051X.2012.01902.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-051X.2012.01902.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T13:07:13Z","timestamp":1700572033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-051X.2012.01902.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,3]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1600-051X.2012.01902.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-051x.2012.01902.x","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,3]]}}}