{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:31:42Z","timestamp":1789018302182,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with flap surgery for the treatment of patients with chronic severe periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty patients with chronic severe periodontitis were treated in a split\u2010mouth study to either adjunctive application of locally delivered minocycline ointment in association with flap surgery (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>) or flap surgery only (<jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content>); additional minocycline application was performed at 3\u00a0months post operation. Clinical evaluation of the plaque index, probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>), gingival recession, and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) was conducted at baseline and at 3 and 6\u00a0months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical evaluations revealed that although both sites exhibited clinical improvement, there was a statistically significant reduction in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> (3.34\u00a0\u00b1\u00a00.03\u00a0mm) and <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> (78.01\u00a0\u00b1\u00a011.42%), and a significant gain of <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> (1.88\u00a0\u00b1\u00a00.21\u00a0mm) at the <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> site compared with the <jats:styled-content style=\"fixed-case\">FO<\/jats:styled-content> site (reduction of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>: 2.62\u00a0\u00b1\u00a00.06\u00a0mm, 50.33\u00a0\u00b1\u00a015.01%, and gain of <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>: 1.55\u00a0\u00b1\u00a00.13\u00a0mm) at 6\u00a0months post operation (<jats:italic>p<\/jats:italic>\u00a0&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjunctive application of locally delivered minocycline may be beneficial to the surgical treatment protocol of chronic severe periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-051x.2012.01908.x","type":"journal-article","created":{"date-parts":[[2012,5,8]],"date-time":"2012-05-08T12:04:35Z","timestamp":1336478675000},"page":"753-759","source":"Crossref","is-referenced-by-count":13,"title":["The clinical effect of locally delivered minocycline in association with flap surgery for the treatment of chronic severe periodontitis: a split\u2010mouth design"],"prefix":"10.1111","volume":"39","author":[{"given":"Dong\u2010Yeol","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"},{"name":"National Health Insurance Corporation Ilsan Hospital Ilsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Chul","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration 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