{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:31:27Z","timestamp":1788280287870,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T00:00:00Z","timestamp":1171411200000},"content-version":"vor","delay-in-days":2876,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>In a controlled double\u2010blind experimental study, patients with contact allergy to nickel or gold were exposed systemically to their contact allergen. Nickel sulfate was given orally, gold sodium thiomalate intramuscularly, and placebo by both routes. Clinical reactions including body temperature were followed and 7 plasma cytokines and acute phase reactants were assayed before and 24 h after provocation. Clinical flare\u2010up, with reactivation of healing patch tests and\/or toxicoderma\u2010like reactions, was observed in patients receiving their specific allergen. A transient fever was noted in patients allergic to gold when exposed to gold, not in others. There was a significant increase in plasma tumour necrosis factor\u2010\u03b1, soluble tumour necrosis factor receptor 1, inter leukin\u20101 receptor antagonist, and neutrophil gelatinase associated lipocalin in patients allergic to gold when exposed to gold allergen. Furthermore, in patients allergic to nickel exposed to nickel allergen there was a highly significant increase in plasma soluble tumour necrosis factor receptor 1. Interferon\u2010gamma, interleukin\u20104, and C\u2010reactive protein did not increase in any of the patient groups. Clinical reactions during flare\u2010up in contact allergy are accompanied by release in the blood of several cytokines. This release is not a consequence of a toxic effect or bound to a particular allergen. Instead, the cytokine release should be considered a general phenomenon characteristic of the flare\u2010up in contact allergy.<\/jats:p>","DOI":"10.1111\/j.1600-0536.1999.tb06034.x","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T03:30:34Z","timestamp":1171510234000},"page":"200-204","source":"Crossref","is-referenced-by-count":71,"title":["The flare\u2010up reactions after systemic provocation in contact allergy to nickel and gold"],"prefix":"10.1111","volume":"40","author":[{"given":"Halvor","family":"M\u00f6ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Ohlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Linder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Bj\u00f6rkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"15","article-title":"Reactions from systemic exposure to contact allergens","volume":"1","author":"Menn\u00e9 T","year":"1982","journal-title":"Semin Dermatol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1015.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2340\/0001555577474479","article-title":"Morphology of endogenous flare\u2010up reactions in contact allergy to gold","volume":"77","author":"Larsson \u00c5","year":"1997","journal-title":"Acta Dermato-venereologica"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(98)90140-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365519509110257"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365519609088801"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517209102748"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb04943.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1997.0278"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.4.1398"},{"key":"e_1_2_1_12_2","article-title":"Flare\u2010up reactions after oral challenge with nickel in relation to challenge dose, intensity and time of previous patch test reactions","author":"Hinds\u00e9n M","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1951.38"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02135.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1975.tb05354.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2340\/0001555567321325","article-title":"Oral challenge with nickel and cobalt in patients with positive patch tests to nickel and\/or cobalt","volume":"67","author":"Veien N K","year":"1987","journal-title":"Acta Dermato-venereologica"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.1999.tb06034.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.1999.tb06034.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:34:00Z","timestamp":1700760840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.1999.tb06034.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1111\/j.1600-0536.1999.tb06034.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.1999.tb06034.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}