{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:47:57Z","timestamp":1792007277435,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T00:00:00Z","timestamp":1154908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>So\u2010called anti\u2010irritants (AI) are widely used in cosmetic formulations, with the aim of reducing irritation from substances in the formulation. It may also be claimed that they are \u2018soothing\u2019 and \u2018healing\u2019 ingredients. However, the proof for these claims is circumstantial. The dose\u2013response effect of 4 alleged AI (nifedipine, (\u2010)\u2010\u03b1\u2010bisabolol, canola oil and glycerol) was studied on experimentally induced acute irritation in healthy volunteers, and only glycerol showed dose\u2010related response and effects potentially better than no treatment. The acute irritation model only allowed a small window of opportunity in which to demonstrate efficacy. Therefore, the effect of AI was studied in a cumulative irritation model by inducing irritant dermatitis with 10\u2003min daily exposures for 5\u2003+\u20034 days (no irritation on weekend) to 1% sodium lauryl sulfate on the right and 20% nonanoic acid on the left volar forearm. AI ointments were applied twice daily. Clinical scoring was performed daily, evaporimetry (Trans Epidermal Water Loss), hydration and colourimetry were measured at baseline (D0), in the middle and at the end of treatment. The glycerol ointment was the only treatment statistically better than both \u2018no treatment\u2019 and vehicle.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2006.00756.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T15:15:38Z","timestamp":1154963738000},"page":"155-159","source":"Crossref","is-referenced-by-count":19,"title":["Anti\u2010irritants II: efficacy against cumulative irritation"],"prefix":"10.1111","volume":"55","author":[{"given":"Flemming","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Hedegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Kongstad","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Ejner","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,7]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"317","article-title":"Use of anti\u2010irritants in cosmetic formulating","volume":"16","author":"Goldemberg R L","year":"1965","journal-title":"J Soc Cosmet Chemists"},{"key":"e_1_2_6_3_2","first-page":"415","article-title":"Anti\u2010Irritants","volume":"30","author":"Goldemberg R L","year":"1979","journal-title":"J Soc Cosmet Chemists"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00752.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1981.tb04059.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06082.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00041.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00208.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-725X.2006.00133.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00175.x"},{"key":"e_1_2_6_11_2","first-page":"117","volume-title":"Experimental Designs","author":"Cochran W","year":"1957"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02258.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1990.tb01553.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056341"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00174.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"e_1_2_6_17_2","first-page":"36","volume-title":"Normal Mixed Models. 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