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Such determinations also facilitate distinctions being drawn between the prevalence of skin sensitization to a particular contact allergen and inherent potency. The distinction is important because chemicals that are implicated as common causes of contact allergy are not necessarily potent sensitizers. One example is provided by nickel that is undoubtedly a common cause of allergic contact dermatitis, but is a comparatively weak sensitizer in predictive tests. In an attempt to explore other examples of contact allergens where there may exist a discrepancy between prevalence and potency, we describe here analyses conducted with methyl methacrylate (MMA). Results of LLNA studies have been interpreted in the context of historical clinical data on occupational allergic contact dermatitis associated with exposure to MMA.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2006.00898.x","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T15:15:38Z","timestamp":1154963738000},"page":"140-147","source":"Crossref","is-referenced-by-count":32,"title":["Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea\u2010pig data and human experience"],"prefix":"10.1111","volume":"55","author":[{"given":"Catherine J.","family":"Betts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Dearman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon R.","family":"Heylings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Basketter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/59.2.198"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00223-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470601.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(91)90167-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03351.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02144.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07677-4_122"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(92)90153-C"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<261::AID-JAT572>3.0.CO;2-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1994.1101"},{"key":"e_1_2_6_12_2","first-page":"589","volume-title":"Immunotoxicology and Immunopharmacology","author":"Friedmann P S","year":"1994"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03279-O"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03114-U"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042006344.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajcd.2001.23926"},{"key":"e_1_2_6_17_2","first-page":"197","article-title":"Contact allergy to medicaments used in dentistry. 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