{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:05:21Z","timestamp":1771013121833,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>10% of patch\u2010tested patients have a positive reaction to gold. Most lack clinical symptoms, but allergic contact dermatitis (ACD) to gold is increasing. In this study, 77 dermatological outpatients were divided into 3 groups depending on epicutaneous patch test outcomes: a group positive to gold (EPI+), a group negative to gold (EPI\u2212), and a group with irritant reactions to gold (EPI\u2010IR). Lymphocytes were stimulated <jats:italic>in vitro<\/jats:italic> with gold sodium thiosulfate. Proliferation was assessed using the lymphocyte transformation test (LTT), and cytokine secretion was assessed using a multibead array (Luminex<jats:sup>\u00ae<\/jats:sup>; Linco Research Inc., St. Charles, MO, USA), in order to evaluate whether an <jats:italic>in vitro<\/jats:italic> method with high diagnostic accuracy could be devised. The EPI+ group showed a significantly increased secretion of interferon (IFN)\u2010\u03b3, interleukin (IL)\u20102, and IL\u201013 and also showed a significantly higher stimulation indexes for LTT, compared to the other 2 subject groups. Sensitivity and specificity were calculated for all methods individually and combined, but IFN\u2010\u03b3 assessment alone was the most accurate method for identifying ACD to gold, with sensitivity and specificity of 81.8% and 82.1%, respectively. This method also identified 87.5% of the EPI\u2010IR subjects as non\u2010allergic. Therefore, assessment of secretion of IFN\u2010\u03b3 should be a valuable complement to patch test for diagnosing gold allergy.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2006.00908.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T18:08:25Z","timestamp":1152554905000},"page":"98-109","source":"Crossref","is-referenced-by-count":15,"title":["Interferon\u2010\u03b3 secreted from peripheral blood mononuclear cells as a possible diagnostic marker for allergic contact dermatitis to gold"],"prefix":"10.1111","volume":"55","author":[{"given":"Jenny","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"F\u00e4rm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Eid\u2010Forest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Cederbrant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hultman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajcd.2001.21472"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70219-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(97)00058-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00194-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/biol.1997.0123"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(85)90037-X"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-8443-4_14"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600876"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016350260248283"},{"key":"e_1_2_6_11_2","first-page":"334","article-title":"Intraoral contact allergy to materials used in dental practice. 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