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EU guidance on regulations concerning the classification of skin sensitizers suggests a range of sources of information be deployed in the hazard identification process. These include chemical structure, predictive animal tests, and various types of human data. Where the information is clear\u2010cut, then uncertainties rarely arise. However, for some materials, discordant information arises, perhaps because the substance is on the borderline of test sensitivity and classification (sensitizing materials of insufficient potency do not classified according to the EU scheme), due to conflicting results in predictive tests or for other reasons. In this study, we review data on a number of substances where a classification decision is complicated by such discordances and seek to use these examples to demonstrate how best to make a weight of evidence decision on whether a substance should, or should not, be classified as a skin sensitizer.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2006.00930.x","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T11:33:22Z","timestamp":1160134402000},"page":"268-273","source":"Crossref","is-referenced-by-count":32,"title":["Identification and classification of skin sensitizers: identifying false positives and false negatives"],"prefix":"10.1111","volume":"55","author":[{"given":"David A.","family":"Basketter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McFadden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Jowsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,6]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"1","article-title":"EEC Council Directive 67\/548\/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances","volume":"196","year":"1967","journal-title":"Off J Eur Comm"},{"key":"e_1_2_8_3_2","first-page":"1","article-title":"EEC Council Directive 92\/32\/EEC amending for the seventh time Directive 67\/548\/EEC","volume":"154","year":"1992","journal-title":"Off J Eur Comm"},{"key":"e_1_2_8_4_2","first-page":"1","article-title":"EC Commission Directive 2001\/59\/EC adapting to technical progress for the 28th time Council directive 67\/548\/EEC","volume":"225","year":"2001","journal-title":"Off J Eur Comm"},{"key":"e_1_2_8_5_2","volume-title":"Test Guideline 429: The Local Lymph Node Assay","author":"Organisation for Economic Cooperation and Development","year":"2002"},{"key":"e_1_2_8_6_2","unstructured":"NIH.The murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals\/compounds. 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