{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T05:03:47Z","timestamp":1698728627601},"reference-count":2,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,15]],"date-time":"2007-06-15T00:00:00Z","timestamp":1181865600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme capable of digesting collagen. Preparations containing clostridiopeptidase A are used topically for the debridement of dermal ulcers, burns and other necrotic lesions to facilitate the formation of granulation tissue and subsequent epithelization. We observed 4 patients with a periulcerative eczema after repeated applications of Noruxol<jats:sup>\u00ae<\/jats:sup> ointment (Smith &amp; Nephew Ltd, L Hull, UK). Patch testing with Noruxol<jats:sup>\u00ae<\/jats:sup> ointment as is and its excipients (soft paraffin and white petrolatum), as well as scaled dilutions of the main ingredient of this topical preparation, clostridiopeptidase A (Firma, Florence, Italy), showed doubtful reactions to Noruxol<jats:sup>\u00ae<\/jats:sup> ointment in 3 patients and a positive reactions only in 1 patient. All patients showed positive reactions to clostridiopeptidase A 1% in pet. This study shows the sensitizing capacity of clostridiopeptidase A that should be tested in all patients with suspect sensitization to Noruxol<jats:sup>\u00ae<\/jats:sup> ointment.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2006.01056.x","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T13:59:06Z","timestamp":1182002346000},"page":"361-362","source":"Crossref","is-referenced-by-count":4,"title":["Contact dermatitis with clostridiopeptidase A contained in Noruxol<sup>\u00ae<\/sup> ointment"],"prefix":"10.1111","volume":"56","author":[{"given":"Caterina","family":"Foti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Conserva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Casulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Scrimieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,15]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"272","article-title":"Kontakteczem auf Noruxol\u00ae Salbe bei posttraumatischem Ulkus","volume":"25","author":"Meichlb\u00f6ck A","year":"1999","journal-title":"Akt Dermatol"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045003186.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2006.01056.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2006.01056.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:41:42Z","timestamp":1698712902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2006.01056.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":2,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1600-0536.2006.01056.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2006.01056.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}