{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:20:58Z","timestamp":1772223658762,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T00:00:00Z","timestamp":1166054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>The elicitation of a positive patch test reaction in a given individual depends upon the dose of the sensitizer applied, the patch test technique and the occlusion time. The dose is determined by the concentration and volume\/amount of test preparation applied. If the same amount\/volume of a test preparation is applied all the time with the same test technique (same area of skin) and occlusion time, it is appropriate to use concentration as a dose parameter. Most contact sensitizers are incorporated in petrolatum (pet.). With pet. as vehicle, it is impossible to repeatedly apply an exact volume\/amount. This study was performed to investigate the inter\u2010 and intra\u2010individual variation of pet. preparation applied at patch testing by 3 technicians. Weighing demonstrated that the 3 technicians had about the same precision in their pet. application. The investigation demonstrates that there is both an inter\u2010individual (statistically significant) and intra\u2010individual variation in the amounts of pet. applied at patch testing for the 3 technicians. Presently, there is no recommendation on what amount of pet. preparation to apply, which merits a decision to be taken based on thorough investigations on the appropriate volumes of pet. preparation to be applied in various patch test systems.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2007.00985.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T16:56:28Z","timestamp":1166115388000},"page":"38-42","source":"Crossref","is-referenced-by-count":36,"title":["Variation in the amount of petrolatum preparation applied at patch testing"],"prefix":"10.1111","volume":"56","author":[{"given":"Magnus","family":"Bruze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Frick\u2010Engfeldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Gruvberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb03280.x"},{"key":"e_1_2_5_3_2","first-page":"361","article-title":"Patch testing with nickel sulphate under occlusion for five hours","volume":"68","author":"Bruze M","year":"1988","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_4_2","first-page":"709","article-title":"Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects","volume":"53","author":"Friedmann P S","year":"1983","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06154.x"},{"key":"e_1_2_5_6_2","first-page":"241","volume-title":"Occupational and Industrial Dermatology","author":"Webster R C","year":"1987"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04623.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042003144.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2340\/0001555576136140","article-title":"The Allergen Bank: a source of extra contact allergens for the dermatologist in practice","volume":"76","author":"Andersen K E","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00957.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470603.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb00695.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1996.tb07603.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00482.x"},{"key":"e_1_2_5_15_2","first-page":"191","article-title":"Variations in the quantities of petrolatum applied in patch testing","volume":"36","author":"Antoine J L","year":"1988","journal-title":"Derm Beruf Umwelt"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2007.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2007.00985.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:59:42Z","timestamp":1697450382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2007.00985.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,14]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1600-0536.2007.00985.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2007.00985.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,14]]}}}