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However, of these, only the local lymph node assay (LLNA) has actually undergone formal independent assessment to determine the accuracy of the predictions, particularly with respect to the likelihood of false positives and false negatives. Often, efforts to increase the sensitivity of a test (reducing false negatives) tend to increase the number of false positives. In this short review, these issues are discussed in particular relation to the 3 predictive tests available in regulatory toxicology, the guinea\u2010pig maximization test, the occluded patch test of Buehler and the LLNA. A key perspective is that no predictive test is without limitations; having a good appreciation of these limitations is necessary for making the best use of the information derived from these methods.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2007.01009.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T16:56:28Z","timestamp":1166115388000},"page":"1-4","source":"Crossref","is-referenced-by-count":17,"title":["Information derived from sensitization test methods: test sensitivity, false positives and false negatives"],"prefix":"10.1111","volume":"56","author":[{"given":"David A.","family":"Basketter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,14]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1997.1178"},{"issue":"2","key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/026119290203002S03","article-title":"The principles of validation and the ECVAM validation approach","volume":"30","author":"Worth A P","year":"2002","journal-title":"Altern Lab Anim"},{"key":"e_1_2_7_4_2","volume-title":"Contact Allergy Predictive Tests in Guinea Pigs. 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