{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:16:38Z","timestamp":1776978998977,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T00:00:00Z","timestamp":1211500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Cutaneous adverse drug reactions (CADR) during chemotherapy are not rare, but difficult to manage. Case 1, a 49\u2010year\u2010old man was treated with 5\u2010fluorouracil, irinotecan, and oxaliplatin for a pancreatic tumour. He developed a generalized urticaria during his seventh course of chemotherapy. 2\u2003months later, skin tests determined a granisetron allergy with an ondansetron cross\u2010reaction. Substituting the anti\u2010emetic allowed continuation of the chemotherapy. Case 2, a 44\u2010year\u2010old woman, having recurring breast cancer that was treated with doxorubicin, and docetaxel developed a maculo\u2010papular rash (MPR) the day after the first chemotherapy treatment. 2\u2003weeks later, skin tests determined a corticosteroid class A allergy. Using a class C corticosteroid, no other reaction occurred. Case 3, a 44\u2010year\u2010old woman, having breast cancer treated with 5\u2010fluorouracil, cyclophosphamide, and epirubicin developed an MPR after the second chemotherapy treatment. 12\u2003days later, skin tests showed a granisetron allergy. Using alizapride, chemotherapy was continued with no further reaction. CADR necessitate a thorough investigation, modified according to the patient\u2019s chemotherapy treatment chronology and precautions while testing the molecules. Tests are rarely carried out, however, these tests allow for continuation of effective chemotherapy once the responsible agent has been determined. The 3 cases reported underline the role of complementary treatment and the necessity to test those molecules.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2007.01285.x","type":"journal-article","created":{"date-parts":[[2008,5,23]],"date-time":"2008-05-23T12:45:03Z","timestamp":1211546703000},"page":"365-368","source":"Crossref","is-referenced-by-count":10,"title":["Cutaneous adverse drug reactions during chemotherapy: consider non\u2010antineoplastic drugs"],"prefix":"10.1111","volume":"58","author":[{"given":"A. 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