{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:34:27Z","timestamp":1791200067570,"version":"4.2.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,16]],"date-time":"2008-01-16T00:00:00Z","timestamp":1200441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> Photoallergic contact dermatitis from topical ketoprofen (KP), a nonsteroidal anti\u2010inflammatory agent, is a well\u2010known side effect.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To investigate photo\u2010contact allergic reactions to KP and other nonsteroidal anti\u2010inflammatory drugs (NSAIDs), sunscreens, and fragrance components as well as the presence of prolonged photosensitivity related to it.<\/jats:p><jats:p><jats:bold>Patients\/Methods:\u2002<\/jats:bold> From June 1993 to June 2007, 42 patients were patch tested and photopatch tested with the ingredients of a KP preparation and other relevant substances. A questionnaire was performed in order to determine the importance of prolonged photosensitivity; 40\/42 did respond.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> 38 patients showed photo\u2010contact reaction, 1 photoaggravated reaction, and 3 contact allergic (CA) reaction to KP. Simultaneous photo\u2010contact allergic reactions were frequently observed not only to structurally related but also to non\u2010structurally related NSAIDs and sunscreens. Simultaneous CA to fragrance components was common. 1\/3 of the patients reported prolonged photosensitivity, i.e. from 1 up to 14\u2003years after having stopped KP application.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The history is often not a good guidance to determine KP\u2010related (photo) allergic contact dermatitis and the severe clinical symptoms sometimes require hospitalization, and\/or systemic corticosteroids. As for the association between KP and sunscreen intolerance (being 1 of the possible causal factors for recurrent dermatitis), routine standard photopatch testing with KP might be indicated.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2007.01296.x","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T06:54:33Z","timestamp":1202885673000},"page":"159-166","source":"Crossref","is-referenced-by-count":82,"title":["Allergic and photoallergic contact dermatitis from ketoprofen: results of (photo) patch testing and follow\u2010up of 42 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