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Although numerous test protocols have been published, how patients with hypersensitivity reactions to LA are ideally evaluated remains a topic of discussion. This review attempts to generate a comprehensive update on allergic reactions to LA and to present an algorithm that can be used for the evaluation of patients suspected with immediate\u2010 and delayed\u2010type immune reactions. Literature was examined using PubMed\u2010Medline, EMBASE, Biosis and Science Citation Index. Based on the literature, the proposed algorithm may safely and rapidly distinguish between immediate\u2010type and delayed\u2010type allergic immune reactions.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2008.01366.x","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T08:05:23Z","timestamp":1217232323000},"page":"69-78","source":"Crossref","is-referenced-by-count":81,"title":["Hypersensitivity to local anaesthetics \u2013 update and proposal of evaluation algorithm"],"prefix":"10.1111","volume":"59","author":[{"given":"Jacob Pontoppidan","family":"Thyssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Elberling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Plaschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,28]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"1742","article-title":"Historical notes on the beginning of local anaesthesia","volume":"90","author":"Koller C","year":"1928","journal-title":"JAMA"},{"key":"e_1_2_9_3_2","first-page":"71","article-title":"Local anaesthetic adverse effects and other emergency problems in general dental practice","volume":"36","author":"Milgrom P","year":"1986","journal-title":"Int Dent J"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90427-6"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90211-2"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9702500602"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)80067-4"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1979.0148"},{"key":"e_1_2_9_9_2","first-page":"176","article-title":"Allergy to local anesthetics in dentistry. 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