{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:19:09Z","timestamp":1792088349744,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T00:00:00Z","timestamp":1280793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p> <jats:italic>Background:<\/jats:italic> Methylchloroisothiazolinone\/methylisothiazolinone (MCI\/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial products, and the first cases of isolated MI contact allergy were published.<\/jats:p><jats:p> <jats:italic>Objectives:<\/jats:italic> To present the prevalence and causes of MI contact allergy.<\/jats:p><jats:p> <jats:italic>Materials and methods:<\/jats:italic> Patch test results from 2536 dermatitis patients tested with MI at Gentofte University Hospital between May 2006 and February 2010 were analysed. A retrospective investigation of medical records from MI\u2010allergic patients was performed to reveal the causes of their MI contact allergy.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic> Of patch\u2010tested patients, 1.5% had MI contact allergy. It was associated with occupational dermatitis, hand eczema and age above 40 years. Exposure to MI in cosmetic products was found in 12 (32%) cases, and exposure to MI in occupational products was found in 11 (30%) cases; 5 of the 11 were painters.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic> The prevalence of MI contact allergy is already at the same level as that of other sensitizing preservatives, which have been on the market for several years, but no rising trend was identified. MI contact allergy was associated with both occupational and consumer products.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2010.01774.x","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T12:08:32Z","timestamp":1295438912000},"page":"164-167","source":"Crossref","is-referenced-by-count":99,"title":["Prevalence and cause of methylisothiazolinone contact allergy"],"prefix":"10.1111","volume":"63","author":[{"given":"Michael D.","family":"Lundov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01501.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06200.x"},{"key":"e_1_2_5_4_2","unstructured":"Anon.SPIN Substances in Preparations In Nordic Countries.2010April 9."},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00629.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00223-0"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1081\/CUS-120026299"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2340\/0001555567315320","article-title":"Contact allergy to the active ingredients of Kathon CG in the guinea pig.","volume":"67","author":"Bruze M","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01668.x"},{"key":"e_1_2_5_10_2","unstructured":"European Commission.Council Directive 76\/768\/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (Consolidated version).2008."},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","unstructured":"European Commission.Regulation (EC) No 648\/2004 of The European Parliament and of the Council of 31 March 2004 on detergents 2004.","DOI":"10.1016\/S1351-4210(04)00295-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00850.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04017"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_5_15_2","first-page":"287","article-title":"Terminology of contact dermatitis.","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_16_2","first-page":"47","article-title":"Voluntary registration of cosmetics and 2007 frequency of preservative use.","volume":"123","author":"Steinberg D C.","year":"2008","journal-title":"Cosmet Toiletries Mag"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01224.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2010.01774.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2010.01774.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T14:15:38Z","timestamp":1697465738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2010.01774.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1111\/j.1600-0536.2010.01774.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2010.01774.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,3]]}}}