{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:20:55Z","timestamp":1791379255049,"version":"4.3.2"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T00:00:00Z","timestamp":1317772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Very few studies are available in which the components of henna products used by tattoo artists have been analysed.<\/jats:p><jats:p><jats:bold>Objective.<\/jats:bold> The aim of this study was to quantify the amounts of lawsone (2\u2010hydroxy\u20101,4\u2010naphthoquinone, the active ingredient in henna) and <jats:italic>p<\/jats:italic>\u2010phenylenediamine (PPD) in products used by tattoo artists and in commercial henna preparations used as hair dyes or to create temporary tattoos.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> We used high\u2010performance liquid chromatography to detect and quantify lawsone and PPD concentrations in three products used by henna tattoo artists, 11 commercially available henna preparations, and a batch of henna leaves (<jats:italic>Lawsonia inermis<\/jats:italic>).<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The henna leaves contained 1.85\u20131.87% lawsone. Only one of the three preparations used by tattoo artists contained lawsone (0.21\u20130.35%), and all three were adulterated with PPD (1\u201364%). Of the 11 commercial henna preparations analysed, nine contained lawsone (1\u20132%) and two contained PPD (2% and 12%).<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Products purporting to be henna, but that in fact contain no henna, are being offered. Moreover, these products may contain PPD, which is associated with health risks, especially severe allergic reactions.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2011.01992.x","type":"journal-article","created":{"date-parts":[[2011,10,5]],"date-time":"2011-10-05T17:18:40Z","timestamp":1317835120000},"page":"33-37","source":"Crossref","is-referenced-by-count":55,"title":["Quantification of <i>p<\/i>\u2010phenylenediamine and 2\u2010hydroxy\u20101,4\u2010naphthoquinone in henna tattoos"],"prefix":"10.1111","volume":"66","author":[{"given":"Pablo J.","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisenda","family":"Pulido\u2010Meli\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Gonz\u00e1lez\u2010D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.05.013"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(96)90031-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05848.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.1.88"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajcd.2002.30466"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470210_11.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.0573e.x"},{"key":"e_1_2_6_9_2","first-page":"25","article-title":"Simultaneous detemination of 1,4\u2010naftoquinone, lawsone, juglone and plumbagin by liquid chromatography with UV detection.","volume":"149","author":"Babula P","year":"2005","journal-title":"Biomed Papers"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1081\/JLC-100001485"},{"key":"e_1_2_6_11_2","author":"Harris D C.","year":"1999","journal-title":"Quantitative Chemical Analysis"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0371-1951(47)80005-0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.06.075"},{"key":"e_1_2_6_14_2","first-page":"779","article-title":"Henna tattooing: cultural tradition meets regulation.","volume":"62","author":"Basas C G.","year":"2007","journal-title":"Food Drug Law J"},{"key":"e_1_2_6_15_2","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios.Riesgos para la salud de los tatuajes temporales a base de \u2018henna negra\u2019 Nota informativa del 16 de Julio de2008. Available at:http:\/\/www.aemps.gob.es\/informa\/notasInformativas\/cosmeticosHigiene\/2008\/docs\/NI\u2010riesgos\u2010henna_julio\u20102008.pdf(last accessed 21 July 2011)."},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/jid.1966.160","article-title":"The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers.","volume":"47","author":"Kligman A M.","year":"1966","journal-title":"J Invest Dermatol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01834.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700223"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00845.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7041681"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2011.01992.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2011.01992.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:37:20Z","timestamp":1698712640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2011.01992.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,5]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1600-0536.2011.01992.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2011.01992.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,5]]}}}