{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:15Z","timestamp":1791073275552,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Contact allergy to cocamidopropyl betaine has been attributed to its impurities dimethylaminopropylamine and cocamidopropyl dimethylamine.<\/jats:p><jats:p>Objectives. To describe patients with positive patch test reactions to cocamidopropyl betaine\u2010related compounds in an occupational dermatology clinic.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> We reviewed the 2002\u20132009 patch test records at the Finnish Institute of Occupational Health for allergic reactions to cocamidopropyl betaine, dimethylaminopropylamine, cocamidopropyl dimethylamine, and oleamidopropyl dimethylamine.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Irritant reactions to at least one of the test substances were seen in 39% of the 1092 patients tested. Fifteen (1.3%) patients showed allergic reactions: 13 to cocamidopropyl dimethylamine, 11 to dimethylaminopropylamine, 8 to oleamidopropyl dimethylamine, and 2 to cocamidopropyl betaine. Concomitant reactions to cocamidopropyl dimethylamine, dimethylaminopropylamine and oleamidopropyl dimethylamine were common. Ten of the 15 patients were diagnosed with occupational allergic contact dermatitis caused by cocamidopropyl betaine\u2010related compounds. The sources of occupational exposure included hair care products, hair colours, perm wave solutions, and liquid soaps. Multiple contact allergies and exposure to several irritant factors were common, and all patients had hand eczema.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Patch test reactions to cocamidopropyl betaine\u2010related compounds are difficult to interpret, owing to extremely common irritant reactions. Cocamidopropyl betaine itself is probably not an allergen. Occupational allergic contact dermatitis caused by cocamidopropyl betaine\u2010related compounds is relatively rare and, unlike non\u2010occupational cocamidopropyl betaine\u2010related allergy, typically manifests as hand dermatitis.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2011.02036.x","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T05:01:08Z","timestamp":1330146068000},"page":"286-292","source":"Crossref","is-referenced-by-count":40,"title":["Occupational contact allergy to cocamidopropyl betaine and its impurities"],"prefix":"10.1111","volume":"66","author":[{"given":"Katri","family":"Suuronen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pesonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"International Cosmetic Ingredient Dictionary and Handbook","author":"Wenninger J A","year":"2000"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01863.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00078.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.20410"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045002072.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04011"},{"key":"e_1_2_6_8_2","first-page":"67","article-title":"Cocamidopropyl betaine; methods for producing CAPB and new analytical methods for determining purity and side product composition.","volume":"112","author":"Gr\u00fcning B","year":"1997","journal-title":"Cosmet Toiletries Mag"},{"key":"e_1_2_6_9_2","first-page":"17.","article-title":"Occupational contact allergy to coconut fatty acid derivatives.","volume":"63","author":"Suuronen K","year":"2010","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00144.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05909.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.20417"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00522.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2310\/6620.2008.06043","article-title":"Cocamidopropyl betaine.","volume":"19","author":"Jacob S E","year":"2008","journal-title":"Dermatitis"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00120.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb05255.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02929.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2011.02036.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2011.02036.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T23:48:52Z","timestamp":1698709732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2011.02036.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1600-0536.2011.02036.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2011.02036.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}