{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:33:31Z","timestamp":1772224411656,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T00:00:00Z","timestamp":1328745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration\/dose has not been evaluated.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To establish the optimal patch test doses in mg\/cm<jats:sup>2<\/jats:sup> for the 12 fragrance substances that are not included in fragrance mix I or II in the European baseline patch test series.<\/jats:p><jats:p><jats:bold>Materials and Methods.<\/jats:bold> Patch testing with the 12 fragrance substances was performed in a stepwise manner encompassing up to five rounds in at least 100 dermatitis patients for each round. Before patch testing, an individual maximum concentration\/dose was determined for each fragrance substance.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The predetermined maximum patch test concentrations\/doses could be tested for all 12 fragrance substances, with no observable adverse reactions being noted.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> For each fragrance substance investigated, it is recommended that half of the maximum patch test dose (mg\/cm<jats:sup>2<\/jats:sup>) be used for aimed and screening patch testing.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2011.02037.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T10:22:51Z","timestamp":1328782971000},"page":"131-136","source":"Crossref","is-referenced-by-count":35,"title":["Patch test concentrations (doses in mg\/cm<sup>2<\/sup>) for the 12 non\u2010mix fragrance substances regulated by European 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formaldehyde.","volume":"119","author":"Bruze M.","year":"1985","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00939.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00605.x"}],"container-title":["Contact 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