{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:35:43Z","timestamp":1793367343809,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Genetic variations in genes coding for cytokines involved in skin inflammation may alter their expression, thus changing the susceptibility to irritant contact dermatitis (ICD).<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To determine the prevalence of polymorphisms in the cytokine genes <jats:italic>TNFA<\/jats:italic>\u2010238 and <jats:italic>TNFA<\/jats:italic>\u2010308 in patients with occupational ICD, and to compare it with that in controls.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> In a case\u2013control study, 478 patients with occupational ICD of the hands were genotyped for <jats:italic>TNFA<\/jats:italic>\u2010238 and <jats:italic>TNFA<\/jats:italic>\u2010308 polymorphisms. The results were compared with those for 393 apprentices from the same high\u2010risk occupations (controls).<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> For a carrier of a variant <jats:italic>TNFA<\/jats:italic>\u2010238A allele, the odds ratio (OR) of acquiring ICD was 0.57 [95% confidence interval (CI) 0.34\u20130.97], suggesting a protective effect of the A allele. The genotype distributions were 94.4% wild type (G\/G), 5.6% heterozygous (G\/A) and 0% homozygous for variant allele (A\/A) in patients, and 90.9%, 8.5%, and 0.6%, respectively in controls. In contrast, carriers of the variant <jats:italic>TNFA<\/jats:italic>\u2010308A allele had an increased risk of ICD [OR 1.33; 95% CI 1.05\u20131.74; G\/G 66.4%, G\/A 31.2%, and A\/A 2.4% (patients) versus 73.5%, 24.6%, 1.9% in controls].<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Individuals with a <jats:italic>TNFA<\/jats:italic>\u2010238 polymorphism are less prone and those with a <jats:italic>TNFA<\/jats:italic>\u2010308 polymorphism are more prone to develop ICD of the hands, suggesting a protective versus a detrimental effect of the A allele respectively.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2011.02045.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T18:52:44Z","timestamp":1331146364000},"page":"221-227","source":"Crossref","is-referenced-by-count":35,"title":["Impact of tumour necrosis factor\u2010<i>\u03b1<\/i> polymorphisms on irritant contact 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