{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:35:06Z","timestamp":1783020906959,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Cosmetic products are known to be able to induce contact dermatitis. Contact dermatitis may also be induced by nickel, and it is estimated that up to 17% of women are allergic to nickel.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> The aim of the present study was to investigate whether nickel sensitized individuals react to make\u2010up products containing pigments with nickel as an impurity.<\/jats:p><jats:p><jats:bold>Patients\/Materials\/Methods.<\/jats:bold> Twenty\u2010three individuals with a clinical history of nickel allergy and\/or with positive patch test reactions to nickel were exposed to mineral make\u2010up products and individual pigments dispersed in alkylbenzoate (50%) in small Finn Chambers<jats:sup>\u00ae<\/jats:sup> for 48 hr. The skin reactions were evaluated visually and with a non\u2010invasive instrument that quantifies skin erythema.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The results showed that 74% of the included individuals showed a visible reaction to the positive control nickel sulfate, and a significant correlation was found between the visual and instrumental readings. However, none of the nickel sensitive individuals reacted to the test products. A subgroup analysis of the 50% most sensitive individuals also confirmed the absence of skin reactions to the powders.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The bioavailability of the trace amounts of nickel in the particles was below the level needed to elicit an eczematous reaction in any of the nickel\u2010sensitized individuals.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02040.x","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T18:52:44Z","timestamp":1331146364000},"page":"210-214","source":"Crossref","is-referenced-by-count":3,"title":["No skin reactions to mineral powders in nickel\u2010sensitive subjects"],"prefix":"10.1111","volume":"66","author":[{"given":"Marie","family":"Lod\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masomeh","family":"Parvardeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Neimert Carne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410025921"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02223.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2002.00152.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx9002726"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042001005.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00149.x"},{"key":"e_1_2_6_8_2","first-page":"9","article-title":"Effects of pretreatment with a urea\u2010containing emollient on nickel allergic skin reactions.","volume":"84","author":"Kuzima N","year":"2004","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00253.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08981.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01815.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/000155501753279596"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1971.51.4.702"},{"key":"e_1_2_6_14_2","first-page":"27","article-title":"The synthetic peptide GRF (1\u201329)\u2010NH2 with growth hormone releasing activity penetrates human epidermis in vitro.","volume":"25","author":"Lod\u00e9n M","year":"1988","journal-title":"Acta Pharm Suec"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03533.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12809.x"},{"key":"e_1_2_6_17_2","first-page":"91","volume-title":"Nickel and the Skin: Immunology and Toxicology","author":"Lammintausta K","year":"1989"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/10408440601177780"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08095.x"},{"key":"e_1_2_6_20_2","unstructured":"NilssonG E.Influence of skin pigmentation in polarization spectroscopy imaging for assessment of erythema and blanching. In:ISBS Symposium Tampa FL 6\u20139 April2011."},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03506.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01910.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02040.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02040.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T15:36:18Z","timestamp":1698766578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02040.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,7]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02040.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02040.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,7]]}}}