{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:47Z","timestamp":1791073307677,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,5]],"date-time":"2012-05-05T00:00:00Z","timestamp":1336176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The preservative methylchloroisothiazolinone (MCI)\/methylisothiazo\u2010 linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch test) can be observed, either overall, or in certain subgroups defined by causative exposures.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> On the basis of long\u2010term contact allergy surveillance data collected by the Information Network of Departments of Dermatology (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ivkd.org\">www.ivkd.org<\/jats:ext-link>), 1992\u20132010, in the course of 171 883 consultations, the time trend of (different grades of) positive patch test reactions to MCI\/MI (0.01% aqua) was examined in an age\u2010stratified analysis.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The overall frequency of positive patch test reactions was 2.33% (95% confidence interval 2.26\u20132.4%). No significant overall trend of positive reactions or of the distribution of +, ++ and + + + reactions (<jats:italic>p<\/jats:italic> &gt; 0.05) was observed, similarly to what was found for patients in whom cosmetics were recorded as causative exposure (<jats:italic>p<\/jats:italic> = 0.55). In contrast, in patients with occupational contact dermatitis who were &lt; 40 years of age, a significant increase in prevalence, by 0.87 percentage points per decade, was identified (<jats:italic>p<\/jats:italic> = 0.018).<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Both applications of MCI\/MI, cosmetic and industrial, should be the target of further preventive efforts.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02075.x","type":"journal-article","created":{"date-parts":[[2012,5,5]],"date-time":"2012-05-05T18:34:21Z","timestamp":1336242861000},"page":"125-129","source":"Crossref","is-referenced-by-count":37,"title":["Methylchloroisothiazolinone\/methylisothiazolinone contact sensitization: diverging trends in subgroups of IVDK patients in a period of 19 years"],"prefix":"10.1111","volume":"67","author":[{"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Gefeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01572.x"},{"key":"e_1_2_6_4_2","first-page":"10","article-title":"The Cosmetics Directive of the European Union. Dir. 89\/174\/EEC. Annex VI: list of preservatives which cosmetic products may contain.","volume":"64","author":"Anonymous.","year":"1989","journal-title":"Off J Eur Commun"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10915819209141993"},{"key":"e_1_2_6_6_2","volume-title":"Opinion on the Mixture of 5\u2010chloro\u20102\u2010 methylisothiazolin\u20103(2H)\u2010one and 2\u2010methylisothiazolin\u20103(2H)\u2010one (SCCS\/1238\/09)","author":"Scientific Committee on Consumer Safety.","year":"2009"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00629.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03360895"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01939.x"},{"key":"e_1_2_6_10_2","first-page":"36","article-title":"Epidemiology of contact dermatitis. The Information Network of Departments of Dermatology (IVDK) in Germany.","volume":"8","author":"Uter W","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.06787.x"},{"key":"e_1_2_6_12_2","unstructured":"R Development Core Team.R: a language and environment for statistical computing Vienna 2010(ISBN 3\u2010900051\u201007\u20100). Available at:http:\/\/www.R\u2010project.org(last accessed 27 March 2012)"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00406.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01313.x"},{"key":"e_1_2_6_15_2","volume-title":"Untersuchungen zur Abh\u00e4ngigkeit der Sensibilisierung gegen wichtige Allergene von arbeitsbedingten sowie individuellen Faktoren (BAuA Fb 949)","author":"Uter W","year":"2002"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01774.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10253.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02075.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02075.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:50:49Z","timestamp":1698738649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02075.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02075.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02075.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,5]]}}}