{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:12:34Z","timestamp":1793157154772,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> It is known that, <jats:italic>in vitro<\/jats:italic>, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize that the molecules of disperse dyes migrate onto the skin while garments are worn, and are metabolized and degraded by commensal skin bacteria. These molecules penetrate the skin and induce sensitization.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To evaluate the elicitation capacities of the possible azo\u2010degradation products of the selected azo disperse dyes in patients allergic to them and to compare it with the elicitation capacities of other para\u2010compunds.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Ten patients allergic to Disperse Yellow 3 (DY3) and\/or Disperse Orange 1 (DO1) were patch tested with a dilution series of the purified dyes 4\u2010nitroaniline and <jats:italic>p<\/jats:italic>\u2010aminodiphenylamine in concentrations equimolar to those of purified DO1 in the dilution series, as well as 4\u2010aminoacetanilide and 2\u2010amino\u2010<jats:italic>p<\/jats:italic>\u2010cresol in concentrations equimolar to those of purified DY3 in the dilution series.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Three patterns of patch test reactions could be seen. The 6 patients who were positive to DO1 and DY3 also reacted to <jats:italic>p<\/jats:italic>\u2010aminodiphenylamine and 2\u2010amino\u2010<jats:italic>p<\/jats:italic>\u2010cresol. Two patients were positive to DO1 only, and both reacted to <jats:italic>p<\/jats:italic>\u2010aminodiphenylamine, but to neither 4\u2010aminoacetanilide or 2\u2010amino\u2010<jats:italic>p<\/jats:italic>\u2010cresol. Two patients did not react to DO1 or DY3 on this occasion.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> We show that it is possible that the major sensitizers in contact allergy to DO1 and DY3 are their metabolites, <jats:italic>p<\/jats:italic>\u2010aminodiphenylamine and 2\u2010amino\u2010<jats:italic>p<\/jats:italic>\u2010cresol, respectively, which might be formed by the azoreductase pathway of skin bacteria.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02080.x","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T04:25:15Z","timestamp":1337919915000},"page":"130-140","source":"Crossref","is-referenced-by-count":14,"title":["Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para\u2010amino compounds"],"prefix":"10.1111","volume":"67","author":[{"given":"Laura","family":"Malinauskiene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Ryberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"European Commission's 6th Framework Programme.Novel sustainable bioprocess for European colour industries 2004. 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