{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:00:56Z","timestamp":1773270056089,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T00:00:00Z","timestamp":1337904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Although acrylate\/methacrylate allergy has been frequently reported, until now patch testing with this group of allergens has been unwieldy, requiring the application of large supplementary series in most centres.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To formulate and evaluate two mixes of acrylate\/methacrylate allergens in three centres (Malm\u00f6, Singapore, and Leuven).<\/jats:p><jats:p><jats:bold>Patients\/materials\/methods.<\/jats:bold> All patients tested with the baseline series during the study period were also patch tested with the mixes. Mix 1 consisted of: triethyleneglycol diacrylate (TREGDA) 0.1% wt\/wt, 2\u2010hydroxyethyl methacrylate (2\u2010HEMA) 1.0% wt\/wt and ethyleneglycol dimethacrylate 1.0% wt\/wt in petrolatum. Mix 2 consisted of: TREGDA 0.1% wt\/wt and 2\u2010HEMA 2.0% wt\/wt in pet. The separate components of the two mixes were also tested simultaneously.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> There were 25 (5 males; 20 females) positive reactions to mix 1 with 16 in Malm\u00f6, 8 in Singapore, and 1 in Leuven. Positive reactions to mix 2 were seen only in Malm\u00f6, in 8 female patients. Thus, the positive reaction rate for mix 1 was 8.3% overall (Malm\u00f6 7.7%, Singapore 18.6%, and Leuven 2.1%), and that for mix 2 was 2.7% overall (Malm\u00f6 3.8%, Singapore 0%, and Leuven 0%). Of the 16 positive reactions to mix 1 in Malm\u00f6, only 4 were considered to be true allergic reactions, as the component allergen testing gave totally negative results in 12\/16. For mix 2, only 3\/8 positive reactions were considered to be true allergic reactions, as the component testing was negative in 5\/8. Many doubtful (10\u201320%) and positive but non\u2010allergic reactions were recorded, leading to early termination of the study.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Although this was an unsuccessful attempt to formulate an acrylate\/methacrylate mix, our experience will be useful for those embarking on future attempts to do this.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02106.x","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T04:27:35Z","timestamp":1337920055000},"page":"157-161","source":"Crossref","is-referenced-by-count":7,"title":["High frequency of false\u2010positive reactions in attempted patch testing with acrylate\/methacrylate mixes"],"prefix":"10.1111","volume":"67","author":[{"given":"Anthony T.\u2010J.","family":"Goon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Leok","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01440.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00621.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02037.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2310\/6620.2011.10083","article-title":"Correlation between stated and measured concentrations of acrylate\/methacrylate allergens in patch test preparations.","volume":"22","author":"Goon A T J","year":"2011","journal-title":"Dermatitis"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06154.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00922.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01151.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042006315.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02106.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02106.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:51:06Z","timestamp":1698738666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02106.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,25]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02106.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02106.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,25]]}}}