{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:13:44Z","timestamp":1791519224497,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background.<\/jats:bold>\n                    Pine processionary larvae produce urticating hairs (setae) that serve for protection against predators. Setae induce cutaneous reactions in animals and humans. The presence of toxic or allergic mechanisms is a matter of debate.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives.<\/jats:bold>\n                    To detect the presence of allergens in setae and to characterize them.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods.<\/jats:bold>\n                    Setae extracts were characterized by gel staining and immunoblot, with sera from patients with immediate reactions and positive prick test reactions, as well as a rabbit antiserum raised against setae. Setae proteins were fractionated by high\u2010performance liquid chromatography. The most relevant allergen was analysed by matrix\u2010assisted laser desorption\/ionization (MALDI) mass spectrometry (MS), and its sequence was deduced from an expressed sequence tag bank.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    Setae contained at least seven different allergens. The most intense detection corresponded to a protein of MW \u223c 14 000 that was similar to thaumetopoein, a previously described protein with mast cell\u2010degranulating properties. MALDI\u2010MS\u2010based\n                    <jats:italic>de novo<\/jats:italic>\n                    sequencing provided a partial amino acid sequence different from that of the previously described allergen Tha p 1, and it was named Tha p 2. This allergen was detected in 61% of patients, and it is therefore a new major caterpillar allergen.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    Penetration of the setae from the pine processionary caterpillar delivers their allergenic content in addition to causing mechanical or toxic injury.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02107.x","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T13:21:45Z","timestamp":1340025705000},"page":"367-374","source":"Crossref","is-referenced-by-count":56,"title":["Setae from the pine processionary moth (\n                    <i>Thaumetopoea pityocampa<\/i>\n                    ) contain several relevant allergens"],"prefix":"10.1111","volume":"67","author":[{"given":"Ana Isabel","family":"Rodriguez\u2010Mahillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonzalez\u2010Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Yart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Kerdelhu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Camafeita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Garcia Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Petrucco Toffolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Battisti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Roques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Moneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"MalletJ.The Lepidoptera Taxome Project Draft Proposals and Information 2007. Available at:http:\/\/www.ucl.ac.uk\/taxome\/lepnos.html(last accessed 25 May 2012)."},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.11.033"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05673.x"},{"key":"e_1_2_5_5_2","first-page":"289","article-title":"Outbreak of dermatitis caused by pine processionary caterpillar (Thaumetopoea pityocampa) in schoolchildren.","volume":"31","author":"Artola\u2010Bord\u00e1s F","year":"2008","journal-title":"An Sist Sanit Navar"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-008-1567-2"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102027"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00173.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075051"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06652.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7322(87)90025-0"},{"key":"e_1_2_5_12_2","first-page":"325","article-title":"Atmospheric pollution of animal origin: the urticating hairs of the processionary caterpillar (Thaumetopoea pityocampa Schiff.) 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