{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:15:10Z","timestamp":1792088110434,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Sensitization to nickel, cobalt and chromium is frequent in patch test populations. The prevalence is affected by geographical and socio\u2010cultural factors.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To investigate the temporal trend of nickel, cobalt and chromium contact sensitization between 1996 and 2010 in north\u2010eastern Italy.<\/jats:p><jats:p><jats:bold>Patients\/methods.<\/jats:bold> Nineteen thousand and eighty\u2010eight patients (67.2% women and 32.8% men) with suspected allergic dermatitis underwent patch testing with the European baseline series. The associations between nickel, cobalt and chromium sensitization and patient age (in quintiles) and year of patch testing were investigated by means of multivariate logistic regression analysis.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The prevalence of nickel sensitization decreased significantly among younger women (\u226426 years), from 38.3% (1996\u20131998) to 31.9% (2002\u20132004), 28.3% (2005\u20132007) and 29.0% (2008\u20132010), whereas an increase was observed in the 36\u201345\u2010year and 46\u201358\u2010year age groups. The overall prevalence of chromium sensitization dropped from 10.2% (1996\u20131998) to 4.6% (2008\u20132010) among women, and from 11.3% (1996\u20131998) to 5.9% (2008\u20132010) among men. The prevalence of cobalt sensitization increased among younger men (\u226426 years), from 2.7% (1996\u20131998) to 7.3% (1999\u20132001), 9.6% (2002\u20132004), and 6.6% (2005\u20132007).<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Our study showed a decreasing trend of nickel sensitization (only among younger women) and of chromium sensitization in both sexes.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02133.x","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T18:35:21Z","timestamp":1341254121000},"page":"23-31","source":"Crossref","is-referenced-by-count":28,"title":["Nickel, chromium and cobalt sensitization in a patch test population in north\u2010eastern Italy 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