{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:57:09Z","timestamp":1791331029136,"version":"4.3.1"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T00:00:00Z","timestamp":1342224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways. However, in recent years, there has been an increasing interest in the roles that regulatory T cells (Tregs) play in allergic contact dermatitis.<\/jats:p><jats:p>Here, we review briefly the phenotype and function of Tregs, and consider how they may impact on various aspects of skin sensitization, including: inter\u2010individual differences in susceptibility; variations in the potency of chemical allergens; and the prevention of excessive, and potentially damaging, levels of sensitization.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02148.x","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T11:15:37Z","timestamp":1342264537000},"page":"179-183","source":"Crossref","is-referenced-by-count":29,"title":["Immunoregulation of skin sensitization and regulatory T cells"],"prefix":"10.1111","volume":"67","author":[{"given":"Ian","family":"Kimber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Dearman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700819"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070509"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0604352"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq346"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.24"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3150"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01471.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6783"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(01)00287-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460101.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(97)01186-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00334.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000024010"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00881.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(00)01815-9"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283079ea4"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02082.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jdermsci.2011.06.004","article-title":"Regulatory T cells in cutaneous immune responses.","volume":"63","author":"Honda T","year":"2011","journal-title":"J Dermatol Sci"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1178"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self\u2010tolerance maintained by activated T cell expressing IL\u20102 receptor alpha chains (CD25). 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