{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:43:12Z","timestamp":1791952992788,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold> Contact allergy to local anaesthetics is relatively common. Patch testing with benzocaine in the European baseline series is recommended for diagnosis, even though a caine mix has been previously suggested to be superior.<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold> To assess the frequency and patterns of contact allergy to local anaesthetics by using a caine mix (benzocaine, tetracaine, and cinchocaine) in the baseline series, and evaluate its efficiency as compared with benzocaine alone.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> We reviewed the results of 2736 patch tests performed between 2000 and 2010, identifying patients with positive reactions to caine mix or to one of seven local anaesthetics.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> One hundred and twelve patients (4.1%) had at least one allergic reaction to local anaesthetics; 86 were tested with all seven local anaesthetics, resulting in 71 reactions in 53 patients. Cinchocaine gave the most reactions (50.7%); these occurred as a single reaction in 83.3% of patients, mostly with current or past relevance (97%). Benzocaine represented 22.5% of reactions, many of which were non\u2010relevant (44%) or resulting from cross\u2010reactions with para\u2010compounds.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> Almost 70% of allergic reactions to local anaesthetics would have been missed if benzocaine had been used as a screening allergen. This study supports a recommendation to replace benzocaine with a caine mix containing cinchocaine in the baseline patch test series.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02149.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T21:40:20Z","timestamp":1342820420000},"page":"156-162","source":"Crossref","is-referenced-by-count":37,"title":["Contact allergy to local anaesthetics\u2013value of patch testing with a caine mix in the baseline 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