{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:19:10Z","timestamp":1792088350470,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The frequency of sensitization to methylchloroisothiazolinone (MCI)\/ methylisothiazolinone (MI) observed in the Information Network of Departments of Dermatology (IVDK) was constantly around 2.1% from 1998 to 2009. After that, it increased to 3.9% in 2011, paralleled by an increase in the frequency of allergic reactions to MI in the preservative series from 1.9% in 2009 to 4.4% in 2011. MI without MCI has increasingly been used as a preservative in cosmetics and skin care products in recent years.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To epidemiologically investigate the possible reasons for this development and to analyse concomitant reactions to MCI\/MI and MI.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> A retrospective analysis of IVDK data from 2009 to 2011 was performed.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Stratified data analysis revealed pronounced increases in reactivity to MCI\/MI and MI in females, face dermatitis patients, and patients tested because of suspected cosmetic intolerance. The proportion of MI\u2010positive patients among those reacting to MCI\/MI increased from 43% to 59% between 2009 and 2011.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> More widespread consumer exposure has most likely led to the increase in primary sensitization to MI and subsequently to a rise in MCI\/MI reactions resulting from immunological cross\u2010reactions. A reduction in the maximum use concentration of MI seems advisable. MI should be patch tested in the baseline series.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02157.x","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T06:11:09Z","timestamp":1348207869000},"page":"334-341","source":"Crossref","is-referenced-by-count":139,"title":["Recent increase in allergic reactions to methylchloroisothiazolinone\/methylisothiazolinone: is methylisothiazolinone the culprit?"],"prefix":"10.1111","volume":"67","author":[{"given":"Johannes","family":"Geier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Lessmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10253.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01939.x"},{"key":"e_1_2_7_5_2","unstructured":"European Commission.Council Directive 76\/768\/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products (consolidated version 01.03.2010) 2010."},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2005.05040"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01811.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03362433"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02075.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-011-2180-3"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02834.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.5414\/DBP53107"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.06787.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02435.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01774.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2340\/0001555567315320","article-title":"Contact allergy to the active ingredients of Kathon CG in the guinea pig.","volume":"67","author":"Bruze M","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx0256634"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.11.002"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx049935"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm064"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.01.014"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0536.2012.02157.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0536.2012.02157.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T03:38:42Z","timestamp":1697513922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0536.2012.02157.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,21]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1600-0536.2012.02157.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0536.2012.02157.x","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,21]]}}}