{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:18:01Z","timestamp":1790529481905,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T00:00:00Z","timestamp":1345852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> It is widely accepted that there is a molecular weight (MW) cut\u2010off of 500, such that single chemicals with MWs higher than 500 cannot be skin sensitizers. If true, this could serve as a useful principle for designing non\u2010sensitizing chemicals.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold> To assess whether the 500 MW cut\u2010off is a myth or a reality.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> A database of 699 chemicals tested for skin sensitization in guinea pigs or mice was analysed to establish the number of tested chemicals with MW &gt; 500, and to establish whether any of these were sensitizers.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Only 13 (2%) of the 699 chemicals in the database have MW &gt; 500. Of the 13 tested compounds with MW &gt; 500 in the database, five are sensitizers and eight are non\u2010sensitizers.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The 500 MW cut\u2010off for skin sensitization is a myth, probably derived from the widespread misconception that ability to efficiently penetrate the stratum corneum is a key determinant of sensitization potency. The scarcity of sensitizers with MW &gt; 500 simply reflects the general scarcity of chemicals with MW &gt; 500.<\/jats:p>","DOI":"10.1111\/j.1600-0536.2012.02160.x","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T09:34:23Z","timestamp":1345887263000},"page":"32-41","source":"Crossref","is-referenced-by-count":25,"title":["What determines skin sensitization potency\u2013myths, maybes and realities. Part 1. The 500 molecular weight cut\u2010off"],"prefix":"10.1111","volume":"68","author":[{"given":"David W.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovanes G.","family":"Mekenyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabcho D.","family":"Dimitrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergana D.","family":"Dimitrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2010.12.014"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00290.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.8.1070-b"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2005.05040"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx0256634"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx049715w"},{"key":"e_1_2_7_8_2","first-page":"81","volume-title":"Allergic Contact Dermatitis. 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